Evaluation Of the Expression Levels Of SerpinB3/B4/B10, Interleukin-17 As Biomarkers For Chronic Rhinosinusitis With Nasal Polyps.

OBJECTIVE

To evaluate the serum expression of SerpinB3/B4/B10 and serum level of interleukin-17 as biomarkers for chronic rhinosinusitis with nasal polyps.

METHODS

This was a cross-sectional study involving 70 patients with CRSwNP and 70 age and gender matched healthy controls. The study patients were assessed using an Arabic version of the Sinonasal Outcome Test 22 score (SNOT-22), an otorhinolaryngology examination, and computed tomography of the nose and paranasal sinuses with grading of the findings using the Lund-Mackay staging system. The patients were divided into 2 subgroups: primary (n = 46) and recurrent (n = 24). Laboratory assessment included an assessment of the serum level of interleukin-17 (IL-17) and the expression of SerpinB3, SerpinB4, and SerpinB10.

RESULTS

The values of IL-17, SerpinB3, SerpinB4, and SerpinB10 were higher in the patient group compared with the control group and in the recurrence subgroup compared with the primary subgroup, with statistically significant differences. All 3 serpins had significant potential as biomarkers for CRSwNP and for differentiating primary from recurrent subtypes, with a p value < .001 for the sensitivity and specificity of all markers. There was a significant positive correlation between the serum expression of each of the serpin markers and the serum levels of IL-17, SNOT 22, and Lund-Mackay score (P < .001 for all).

CONCLUSION

The biomarkers studied had significantly higher values in CRSwNP patients, especially the recurrent subgroup. SerpinB3/B4/B10 had significant sensitivity and specificity as biomarkers for CRSwNP, predicting the likelihood of postoperative polyp recurrence, and showing a positive correlation with disease severity.