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Войти в исследования Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke · 2025
A man in his 60s with immunodeficiency and hepatitis.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
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Hvitmyhr Caroline, Enga Kristin Fjeldstad, Øverbø Joakim, Midgard Håvard, Reikvam Dag Henrik
Аннотация
BACKGROUND: Major causes of elevated liver enzymes are toxic, infectious, neoplastic and autoimmune disease. In immunocompromised patients, the spectrum of infectious pathogens causing hepatitis is broader and the immune response is blunted, making diagnosis more challenging.
CASE PRESENTATION: A man in his sixties had received CAR-T therapy for multiple myeloma.
INTERPRETATION: The increasing number of immunocompromised patients means that more patients are at risk of developing chronic hepatitis E. Serologic tests may be unreliable for this patient population, and nucleic acid testing for HEV RNA should be the primary diagnostic approach. HEV can be contracted in Norway, and hepatitis E is an underdiagnosed infection.
CASE PRESENTATION: A man in his sixties had received CAR-T therapy for multiple myeloma.
INTERPRETATION: The increasing number of immunocompromised patients means that more patients are at risk of developing chronic hepatitis E. Serologic tests may be unreliable for this patient population, and nucleic acid testing for HEV RNA should be the primary diagnostic approach. HEV can be contracted in Norway, and hepatitis E is an underdiagnosed infection.