Journal of psychiatry & neuroscience : JPN · 2026
Differences in cortical gyrification and fractional amplitude of low-frequency fluctuations between early- and late-onset obsessive-compulsive disorder.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Tomiyama Hirofumi, Murayama Keitaro, Nemoto Kiyotaka, Kato Kenta, Nishida Nami, Matsukuma Kou, Kawahito Makoto, Kamio Takuro, Tsunoda Kana, Kang Mingi, Shuto Ayaka, Yamashita Koji, Kikuchi Kazufumi, Wada Tatsuhiro, Tokunaga Chiaki, Nakao Tomohiro
Аннотация
BACKGROUND: Obsessive-compulsive disorder (OCD) is heterogeneous, and differences in age at onset may be associated with important feature of distinct subtype. However, no studies have investigated the differences between early- and late-onset OCD using structural and functional multimodal neuroimaging methods that reflect different neurobiological backgrounds.
METHODS: Structural and resting-state functional magnetic resonance imaging data were obtained from 130 participants (76 medication-free patients with OCD and 54 healthy controls (HCs)). We investigated group differences among early- and late-onset OCD and HCs in the fractional amplitude of low-frequency fluctuation (fALFF) and local gyrification index (LGI).
RESULTS: In the fALFF analysis, group differences were detected in the left lateral occipital cortex and bilateral thalamus (a voxel-height threshold of p < 0.001 and a cluster-level threshold of p < 0.05, with a false discovery rate correction). Both patients with early- and late-onset OCD had significantly lower fALFF in the thalamus compared to HCs (Bonferroni corrected p < 0.01). Patients with early-onset OCD exhibited significantly lower fALFF in the lateral occipital cortex than those with late-onset OCD and HCs (Bonferroni corrected p < 0.01). No significant differences were observed in the LGI analysis (a nonparametric permutation approach (10 000 iterations)), a cluster-wise threshold of p < 0.05, and a cluster-defining threshold of p < 0.001).
LIMITATIONS: Our cross-sectional data could limit the interpretation of our results.
CONCLUSIONS: Our results emphasize the importance of the thalamus in the pathophysiology regardless of the age-of-onset subtype of OCD. In addition, altered fALFF in the lateral occipital cortex, not accompanied by deficits of LGI, could represent a disruption of normal functional developmental processes resulting from the OCD onset at a young age. Future study should examine the relationship between the alteration of fALFF in lateral occipital cortex and clinical and treatment-refractory features of early-onset OCD, potentially improving therapeutic strategies.
METHODS: Structural and resting-state functional magnetic resonance imaging data were obtained from 130 participants (76 medication-free patients with OCD and 54 healthy controls (HCs)). We investigated group differences among early- and late-onset OCD and HCs in the fractional amplitude of low-frequency fluctuation (fALFF) and local gyrification index (LGI).
RESULTS: In the fALFF analysis, group differences were detected in the left lateral occipital cortex and bilateral thalamus (a voxel-height threshold of p < 0.001 and a cluster-level threshold of p < 0.05, with a false discovery rate correction). Both patients with early- and late-onset OCD had significantly lower fALFF in the thalamus compared to HCs (Bonferroni corrected p < 0.01). Patients with early-onset OCD exhibited significantly lower fALFF in the lateral occipital cortex than those with late-onset OCD and HCs (Bonferroni corrected p < 0.01). No significant differences were observed in the LGI analysis (a nonparametric permutation approach (10 000 iterations)), a cluster-wise threshold of p < 0.05, and a cluster-defining threshold of p < 0.001).
LIMITATIONS: Our cross-sectional data could limit the interpretation of our results.
CONCLUSIONS: Our results emphasize the importance of the thalamus in the pathophysiology regardless of the age-of-onset subtype of OCD. In addition, altered fALFF in the lateral occipital cortex, not accompanied by deficits of LGI, could represent a disruption of normal functional developmental processes resulting from the OCD onset at a young age. Future study should examine the relationship between the alteration of fALFF in lateral occipital cortex and clinical and treatment-refractory features of early-onset OCD, potentially improving therapeutic strategies.