Sebum-Selective 1,726-nm Laser Therapy for Papulopustular Rosacea Associated with Demodex Mite Proliferation: A Case Report.

Papulopustular rosacea is a chronic inflammatory condition of the pilosebaceous unit, with an unclear exact cause, but it is thought to involve an exaggerated immune response, persistent inflammation, and possibly an increased presence of Demodex mites on the skin. This is a case report of a 22-year-old woman with papulopustular rosacea treated with a 1,726-nm sebum-selective laser over three sessions. Progressive clinical improvement was observed, with a reduction of inflammatory lesions from 234 at baseline to complete clearance, along with improvement in erythema, flushing, and patient-reported symptoms. Demodex density decreased from 58 mites/cm2 to 12 mites/cm2. Treatment was well tolerated, with no adverse events and high patient satisfaction. These findings suggest that sebum-selective laser therapy may offer a non-pharmacologic treatment option for papulopustular rosacea, potentially by modulating sebaceous gland activity. Further studies are needed to confirm efficacy and clarify mechanisms.