TNF-alpha inhibitor therapy for granuloma annulare.

BACKGROUND

Granuloma annulare (GA) is an inflammatory cutaneous reaction characterized by erythematous, annular skin lesions. The etiology of GA is unknown, and treatment is challenging. The current treatment options include topical or intralesional steroids. Biologics can also be effective.

METHODS

In this paper, we review the current literature on the use of TNF-alpha inhibitor therapy in the treatment of GA.

RESULTS/

CONCLUSION

GA has a positive response to TNF-alpha inhibitors, most notably with etanercept and adalimumab. These findings can aid dermatologists in treating GA that is unresponsive to other therapies.