The Liver in Hematologic Malignancies: Lymphoma, Leukemia, and Myeloma.

Liver disease significantly impacts hematologic malignancies like lymphoma, leukemia, and multiple myeloma. Chronic hepatitis B and C increase risks, complicate treatment, and may lead to reactivation during chemotherapy. Bone marrow transplantation (BMT) is associated with the risk of hepatic complications. Antiviral therapy mitigates risks, improving survival. Screening and prophylactic treatment are essential for managing liver-related complications in these patients. Cirrhosis complicates the treatment of hematologic malignancies by altering drug metabolism, increasing toxicity, and heightening risks of complications. BMT further challenges liver function, with increased risk of complications like sinusoidal obstruction syndrome, requiring specialized management.