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Nature communications · 2022

Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression.

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Larivière Sara, Royer Jessica, Rodríguez-Cruces Raúl, Paquola Casey, Caligiuri Maria Eugenia, Gambardella Antonio, Concha Luis, Keller Simon S, Cendes Fernando, Yasuda Clarissa L, Bonilha Leonardo, Gleichgerrcht Ezequiel, Focke Niels K, Domin Martin, von Podewills Felix, Langner Soenke, Rummel Christian, Wiest Roland, Martin Pascal, Kotikalapudi Raviteja, O'Brien Terence J, Sinclair Benjamin, Vivash Lucy, Desmond Patricia M, Lui Elaine, Vaudano Anna Elisabetta, Meletti Stefano, Tondelli Manuela, Alhusaini Saud, Doherty Colin P, Cavalleri Gianpiero L, Delanty Norman, Kälviäinen Reetta, Jackson Graeme D, Kowalczyk Magdalena, Mascalchi Mario, Semmelroch Mira, Thomas Rhys H, Soltanian-Zadeh Hamid, Davoodi-Bojd Esmaeil, Zhang Junsong, Winston Gavin P, Griffin Aoife, Singh Aditi, Tiwari Vijay K, Kreilkamp Barbara A K, Lenge Matteo, Guerrini Renzo, Hamandi Khalid, Foley Sonya, Rüber Theodor, Weber Bernd, Depondt Chantal, Absil Julie, Carr Sarah J A, Abela Eugenio, Richardson Mark P, Devinsky Orrin, Severino Mariasavina, Striano Pasquale, Tortora Domenico, Kaestner Erik, Hatton Sean N, Vos Sjoerd B, Caciagli Lorenzo, Duncan John S, Whelan Christopher D, Thompson Paul M, Sisodiya Sanjay M, Bernasconi Andrea, Labate Angelo, McDonald Carrie R, Bernasconi Neda, Bernhardt Boris C

Аннотация

Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations, but associations between neurobiological mechanisms and macroscale connectomics remain unclear. This multisite ENIGMA-Epilepsy study examined whole-brain structural covariance networks in patients with epilepsy and related findings to postmortem epilepsy risk gene expression patterns. Brain network analysis included 578 adults with temporal lobe epilepsy (TLE), 288 adults with idiopathic generalized epilepsy (IGE), and 1328 healthy controls from 18 centres worldwide. Graph theoretical analysis of structural covariance networks revealed increased clustering and path length in orbitofrontal and temporal regions in TLE, suggesting a shift towards network regularization. Conversely, people with IGE showed decreased clustering and path length in fronto-temporo-parietal cortices, indicating a random network configuration. Syndrome-specific topological alterations reflected expression patterns of risk genes for hippocampal sclerosis in TLE and for generalized epilepsy in IGE. These imaging-transcriptomic signatures could potentially guide diagnosis or tailor therapeutic approaches to specific epilepsy syndromes.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты