[Nutritional support in the comprehensive management of cutaneous squamous cell carcinoma in congenital epidermolysis bullosa].

UNLABELLED: Congenital epidermolysis bullosa (EB) is a rare genetically heterogeneous disorder characterized by blistering and erosions of the skin and mucous membranes. The dystrophic form of EB is particularly associated with severe complications including cutaneous squamous cell carcinoma (cSCC) and gastrointestinal tract involvement (esophageal strictures, malabsorption). These conditions frequently lead to protein-energy malnutrition, significantly worsening patient prognosis and quality of life. The purpose of the study was to present a clinical case of nutritional support implementation in a patient with dystrophic EB complicated by cSCC.

MATERIAL AND

METHODS

From 2015 to 2025, 79 EB patients (age range 18-74 years, mean age 29.4±11.1 years) were monitored at the Burn Department of the Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia. This cohort represented 62.6% of all registered EB cases in the Russian Federation. cSCC was diagnosed in 14 (17.7%) patients. We present a clinical case demonstrating the impact of nutritional support in an adult patient with dystrophic EB and cSCC.

RESULTS

Timely nutritional intervention was shown to enhance wound healing and overall clinical status, reduce catabolic stress, optimize preparation for antitumor therapy.

CONCLUSION

Our findings emphasize the critical importance of early nutritional support implementation within a multidisciplinary management approach for EB patients with oncological complications. The study demonstrates that appropriate nutritional intervention can significantly improve clinical outcomes in this challenging patient population.