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Войти в исследования ERJ open research · 2026
Lung function across the life course in Kenya: a series of cross-sectional surveys.
СтатьяНазвание и аннотация: Перевод в очереди
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Meme Hellen, Matu Sophie, Orina Fred, Miheso Barbara, Kiplimo Richard, Ndombi Amos, Kathure Immaculate, Kinyanjui James, Amukoye Evans, Chakaya Jeragingh, He Nengjie, Bowyer Cressida, Gray Cindy M, Lesosky Maia, Mortimer Kevin, Semple Sean, West Sarah E, Zurba Lindsay, Binegdie Amsalu B, El Sony Asma, Devereux Graham
Аннотация
BACKGROUND: The high prevalence of COPD in sub-Saharan Africa is poorly understood. In high-income countries, COPD is the consequence of suboptimal lung growth during childhood and/or accelerated lung function decline in adult life. We have conducted cross-sectional studies to measure the lung function of children and adults in Kenya and to identify associations with age.
METHODS: We performed spirometry in three groups in Kenya: a random sample of schoolchildren in two districts of urban Nairobi and age/sex-stratified representative community samples of adults in Nairobi and rural Machakos. Forced expiratory volume in 1 s (FEV1) and forced vital capacity were expressed as z-scores using race-neutral GLI-Global reference equations.
RESULTS: The mean (95% CI) FEV1 z-score in Nairobi schoolchildren (n=2373, median age 10 years (IQR 8-13) 52% girls) was -0.60 (-0.64- -0.55); in Nairobi adults (n=2936, median age 32 years (24-43), 62% female) -0.49 (-0.53- -0.45); and in Machakos adults (n=1607, median age 46 years (35-59), 65% female) -0.67 (-0.72- -0.61). In adults, FEV1 was negatively associated with age (FEV1 z-score regression coefficient β -0.005/year (95% CI -0.009- -0.002) p=0.005, and there was a negative interaction between residence in Nairobi and age, β -0.006/year (95% CI -0.011- -0.001), p=0.020.
CONCLUSION: The lung function of children and adults in Kenya was lower than predicted by race-neutral Global Lung Function Initiative (GLI)-Global reference equations. In adults, a negative association between lung function and age was greater in urban, than in rural, settings. Further work is required to identify and mitigate relevant influences.
METHODS: We performed spirometry in three groups in Kenya: a random sample of schoolchildren in two districts of urban Nairobi and age/sex-stratified representative community samples of adults in Nairobi and rural Machakos. Forced expiratory volume in 1 s (FEV1) and forced vital capacity were expressed as z-scores using race-neutral GLI-Global reference equations.
RESULTS: The mean (95% CI) FEV1 z-score in Nairobi schoolchildren (n=2373, median age 10 years (IQR 8-13) 52% girls) was -0.60 (-0.64- -0.55); in Nairobi adults (n=2936, median age 32 years (24-43), 62% female) -0.49 (-0.53- -0.45); and in Machakos adults (n=1607, median age 46 years (35-59), 65% female) -0.67 (-0.72- -0.61). In adults, FEV1 was negatively associated with age (FEV1 z-score regression coefficient β -0.005/year (95% CI -0.009- -0.002) p=0.005, and there was a negative interaction between residence in Nairobi and age, β -0.006/year (95% CI -0.011- -0.001), p=0.020.
CONCLUSION: The lung function of children and adults in Kenya was lower than predicted by race-neutral Global Lung Function Initiative (GLI)-Global reference equations. In adults, a negative association between lung function and age was greater in urban, than in rural, settings. Further work is required to identify and mitigate relevant influences.