Clinical biochemistry · 2017
The transferrin isoforms in chronic hepatitis.
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Gruszewska Ewa, Wrona Alicja, Gudowska Monika, Panasiuk Anatol, Cylwik Bogdan, Lipartowska-Klimuk Karina, Flisiak Robert, Chrostek Lech
Аннотация
BACKGROUND: The aim of this study was to evaluate the effect of chronic hepatitis on the serum profile of transferrin isoforms.
METHODS: Tested group consist of 160 patients with chronic hepatitis. The samples were analyzed by capillary electrophoresis on MINICAP electrophoretic system (Sebia, France).
RESULTS: In patients with chronic hepatitis tetrasialotransferrin level was increased (P=0.002) and pentasialotransferrin decreased (P=0.009). Moreover, statistical analysis revealed that trisialotransferrin level was different according to the grade of portal/periportal activity (P=0.009), the grade of lobular activity (P=0.004) and the stage of fibrosis (P=0.022). There were no differences in tetrasialotransferrin and pentasialotransferrin according to the advancement of hepatitis activity and the stage of fibrosis (P>0.05 for all comparisons).
CONCLUSIONS: We conclude that chronic hepatitis affect the serum profile of transferrin isoforms, but only trisialotransferrin level could be useful in determining progression of chronic hepatitis and the stage of fibrosis.
METHODS: Tested group consist of 160 patients with chronic hepatitis. The samples were analyzed by capillary electrophoresis on MINICAP electrophoretic system (Sebia, France).
RESULTS: In patients with chronic hepatitis tetrasialotransferrin level was increased (P=0.002) and pentasialotransferrin decreased (P=0.009). Moreover, statistical analysis revealed that trisialotransferrin level was different according to the grade of portal/periportal activity (P=0.009), the grade of lobular activity (P=0.004) and the stage of fibrosis (P=0.022). There were no differences in tetrasialotransferrin and pentasialotransferrin according to the advancement of hepatitis activity and the stage of fibrosis (P>0.05 for all comparisons).
CONCLUSIONS: We conclude that chronic hepatitis affect the serum profile of transferrin isoforms, but only trisialotransferrin level could be useful in determining progression of chronic hepatitis and the stage of fibrosis.