Robust inference and correlates from genetic associations with personality.
Schwaba Ted, Clapp Sullivan Margaret L, Akingbuwa Wonuola A, Ilves Kerli, Tanksley Peter T, Williams Camille M, Dragostinov Yavor, Mallard Travis T, Tubbs Justin D, Liao Wangjingyi, Ackerman Lindsay S, Fealy Josephine C M, Hemani Gibran, de la Fuente Javier, Smith George Davey, Gupta Priya, Stein Murray B, Gelernter Joel, Levey Daniel F, Võsa Urmo, Ausmees Liisi, Realo Anu, Estonian Biobank Research Team, Vaht Mariliis, Allik Jüri, Esko Tõnu, Mõttus René, Vainik Uku, Jonsdottir Gudrun A, Thorleifsson Gudmar, Gunnarsson Árni Freyr, Bjornsdottir Gyda, Thorgeirsson Thorgeir E, Stefansson Hreinn, Stefansson Kari, Cheesman Rosa, Qin Qi, Corfield Elizabeth C, Ask Helga, Torvik Fartein Ask, Ystrom Eivind, Tesli Martin, Boomsma Dorret I, de Geus Eco J C, Hottenga Jouke-Jan, Melo Dener Cardoso, Snieder Harold, Hartman Catharina A, Xia Charley, Campbell Archie, Luciano Michelle, Deary Ian J, Hill W David, Jang Seon-Kyeong, Vrieze Scott I, Abecasis Gonçalo, Lupton Michelle K, Mitchell Brittany L, Viher Petra V, Colodro-Conde Lucía, Martin Nicholas G, Medland Sarah E, Derks Eske M, Wormington Briar, Kaprio Jaakko, Silventoinen Karri, Palviainen Teemu, Musial Agnieszka, Rimfeld Kaili, Plomin Robert, Malanchini Margherita, Dick Danielle M, Aliev Fazil, COGA Collaborators, Spit for Science Working Group, Wesseldijk Laura W, Ullén Fredrik, Mosing Miriam A, Kranzler Henry R, Nunez Yaira, Beck Sarah, Polimanti Renato, Edwards Tobias, Giannelis Alexandros, Willoughby Emily A, Lee James J, McGue Matt, Terracciano Antonio, Marongiu Michele, Fiorillo Edoardo, Cucca Francesco, Sutin Angelina R, van der Most Peter J, Oldehinkel Albertine J, Kretschmer Tina, Shabalin Andrey A, Docherty Anna R, Krueger Robert F, Freilich Colin D, Mishra Binisha H, Lehtimäki Terho, Raitakari Olli T, Kähönen Mika, Saarinen Aino, Dobewall Henrik, Keltikangas-Järvinen Liisa, Berger Klaus, Herrera-Rivero Marisol, Streit Fabian, Awasthi Swapnil, Witt Stephanie H, Tuhkanen Johanna, Räikkönen Katri, Eriksson Johan G, Lahti Jari, Davies Gail, Redmond Paul, Taylor Adele, Corley Janie, Russ Tom C, Ciullo Marina, Nutile Teresa, Ding Jun, Qian Yong, Tanaka Toshiko, Ferrucci Luigi, Zillich Lea, Sirignano Lea, Harden K Paige, Genç Erhan, Gajewski Patrick D, Getzmann Stephan, Fraenz Christoph, Schneider Peñate Javier E, Lis Stefanie, Hall Alisha S M, Schmahl Christian, Herpertz Sabine C, Abdellaoui Abdel, Nivard Michel G, Tucker-Drob Elliot M
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Аннотация
Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustness, their generalizability and the biological and social pathways through which they act. Here we meta-analyse data across 46 cohorts comprising 611,037 to 1.14 million participants with European-like and African-like genomes for genome-wide association studies (GWAS) of the Big Five personality traits (extraversion, agreeableness, conscientiousness, neuroticism and openness to experience), and data from up to 50,725 participants for within-family GWAS. We identify 1,260 lead genetic variants associated with personality, including 824 novel variants3. Common genetic variants explain a moderate 4.8-9.3% of the variance in measures of each trait, and 9.3-13.3% among instruments with typical measurement reliability. Genetic associations with personality are highly consistent but not identical across geography, reporter (self versus close other), age group and measurement instrument, and we find minimal spousal assortment for personality in recent history. In contrast to many other social and behavioural traits4,5, within-family GWAS and polygenic index analyses indicate that genetic associations with personality are minimally confounded by the shared family environment. Polygenic prediction, genetic correlation and Mendelian randomization analyses indicate that personality traits have widespread, potentially causal associations with consequential behaviours and life outcomes. Overall, we find that the genetic architecture of personality is robustly generalizable, minimally confounded and widely relevant to human experience.
Для цитирования: Schwaba Ted, Clapp Sullivan Margaret L, Akingbuwa Wonuola A, Ilves Kerli, Tanksley Peter T, Williams Camille M, Dragostinov Yavor, Mallard Travis T, Tubbs Justin D, Liao Wangjingyi, Ackerman Lindsay S, Fealy Josephine C M, Hemani Gibran, de la Fuente Javier, Smith George Davey, Gupta Priya, Stein Murray B, Gelernter Joel, Levey Daniel F, Võsa Urmo, Ausmees Liisi, Realo Anu, Estonian Biobank Research Team, Vaht Mariliis, Allik Jüri, Esko Tõnu, Mõttus René, Vainik Uku, Jonsdottir Gudrun A, Thorleifsson Gudmar, Gunnarsson Árni Freyr, Bjornsdottir Gyda, Thorgeirsson Thorgeir E, Stefansson Hreinn, Stefansson Kari, Cheesman Rosa, Qin Qi, Corfield Elizabeth C, Ask Helga, Torvik Fartein Ask, Ystrom Eivind, Tesli Martin, Boomsma Dorret I, de Geus Eco J C, Hottenga Jouke-Jan, Melo Dener Cardoso, Snieder Harold, Hartman Catharina A, Xia Charley, Campbell Archie, Luciano Michelle, Deary Ian J, Hill W David, Jang Seon-Kyeong, Vrieze Scott I, Abecasis Gonçalo, Lupton Michelle K, Mitchell Brittany L, Viher Petra V, Colodro-Conde Lucía, Martin Nicholas G, Medland Sarah E, Derks Eske M, Wormington Briar, Kaprio Jaakko, Silventoinen Karri, Palviainen Teemu, Musial Agnieszka, Rimfeld Kaili, Plomin Robert, Malanchini Margherita, Dick Danielle M, Aliev Fazil, COGA Collaborators, Spit for Science Working Group, Wesseldijk Laura W, Ullén Fredrik, Mosing Miriam A, Kranzler Henry R, Nunez Yaira, Beck Sarah, Polimanti Renato, Edwards Tobias, Giannelis Alexandros, Willoughby Emily A, Lee James J, McGue Matt, Terracciano Antonio, Marongiu Michele, Fiorillo Edoardo, Cucca Francesco, Sutin Angelina R, van der Most Peter J, Oldehinkel Albertine J, Kretschmer Tina, Shabalin Andrey A, Docherty Anna R, Krueger Robert F, Freilich Colin D, Mishra Binisha H, Lehtimäki Terho, Raitakari Olli T, Kähönen Mika, Saarinen Aino, Dobewall Henrik, Keltikangas-Järvinen Liisa, Berger Klaus, Herrera-Rivero Marisol, Streit Fabian, Awasthi Swapnil, Witt Stephanie H, Tuhkanen Johanna, Räikkönen Katri, Eriksson Johan G, Lahti Jari, Davies Gail, Redmond Paul, Taylor Adele, Corley Janie, Russ Tom C, Ciullo Marina, Nutile Teresa, Ding Jun, Qian Yong, Tanaka Toshiko, Ferrucci Luigi, Zillich Lea, Sirignano Lea, Harden K Paige, Genç Erhan, Gajewski Patrick D, Getzmann Stephan, Fraenz Christoph, Schneider Peñate Javier E, Lis Stefanie, Hall Alisha S M, Schmahl Christian, Herpertz Sabine C, Abdellaoui Abdel, Nivard Michel G, Tucker-Drob Elliot M. Robust inference and correlates from genetic associations with personality.. Nature. 2026. DOI: 10.1038/s41586-026-10992-9.
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