Медицинская библиотека · Techniques in coloproctology · 2025

COVID-19-specific risk factor for early post-appendectomy complications (EPAC) in older patients: a retrospective study.

Habeeb Tamer A A M, Hussain A, Bueno-Lledó Jose, Giménez M E, Aiolfi A, Chiaretti M, Kryvoruchko I A, Manangi M N, Elias Abd Al-Kareem, Adam Abdelmonem A M, Gadallah Mohamed A, Ahmed Saad Mohamed Ali, Khyrallh Ahmed, Alsayed Mohammed H, Awad Esmail Tharwat Kamel, Ibrahim Emad A, Elshafey Mohammed Hassan, Labib Mohamed Fathy, Badawy Mahmoud Hassib Morsi, Teama Sobhy Rezk Ahmed, Seleem Abdelhafez, Abo Alsaad Mohamed Ibrahim, Ali Abouelatta Kh, Elbelkasi Hamdi, Abou Zaid Mahmoud Ali, Mohamed Basma Ahmed, Alwadees Alaa, El-Taher Ahmed K, Mansour Mohamed Ibrahim, Yassin Mahmoud Abdou, Arafa Ahmed Salah, Lotfy Mohamed, Atef Baher, Elnemr Mohamed, Khairy Mostafa M, Abdelwanis Abdelfatah H, Abdelaziz Ahmed Mesbah, Mostafa Abdelshafy, Hamed AbdElwahab M, Wasefy Tamer, Heggy Ibrahim A, Nawar Abdelrahman Mohamed Hasanin

СтатьяМногоцентровое исследованиеНаблюдательное исследованиеПеревод в очереди

Аннотация

BACKGROUND

The incidence of acute appendicitis in older patients significantly varies from that in younger adults. The coronavirus disease 2019 (COVID-19) pandemic has increased the risk of early post-appendectomy complications (EPAC). This study aimed to investigate the incidence and risk factors associated with EPAC in older patients after appendectomy and to define active COVID-19 infection during surgery as an associated risk factor for EPAC.

METHODS

We conducted a retrospective multicenter analysis of older patients aged ≥ 60 years who underwent appendectomy between April 2020 and December 2024. Logistic regression identified the risk factors associated with EPAC.

RESULTS

A total of 585 patients aged ≥ 60 years were divided into the EPAC (n = 32) and no EPAC (n = 553) groups. The incidences of EPAC was 5.5% (32/585), including superficial incisional surgical site infections (SSI) (9/32, 28.1%), deep incisional SSI (2/32, 6.3%), organ/space infection (2/32, 6.3%), intra-abdominal abscess (9/32, 28.1%), ileus (2/32, 6.3%), pneumonia (3/32, 9.4%), acute myocardial infraction (MI) (2/32, 6.3%), fecal fistula (2/32, 6.3%), and acute adhesive intestinal obstruction (1/32, 3.1%). Multivariable analysis identified that active COVID-19 infection during surgery (odds ratio (OR) = 25.9; 95% confidence interval (CI) 4.8-139.1; p < 0.001), American Society of Anesthesiologists (ASA) score ≥ II (OR = 4.5; 95% CI 1.2-17.07; p = 0.02), open approach (OR = 30.6; 95% CI 8.1-115.3; p < 0.001), and high-grade appendicitis ≥ IV (OR = 63.06; 95% CI 7.5-526.4; p < 0.001) were significant associated risk factors for EPAC.

CONCLUSIONS

The incidence of EPAC in older patients after appendectomy is 5.5%. Active COVID-19 infection during surgery is strongly associated with an increased risk of EPAC. COVID-19 should be considered in perioperative risk assessment of EPAC.

TRIAL REGISTRATION: This study was registered as a clinical trial (NCT06787573). Retrospectively registered.

Для цитирования: Habeeb Tamer A A M, Hussain A, Bueno-Lledó Jose, Giménez M E, Aiolfi A, Chiaretti M, Kryvoruchko I A, Manangi M N, Elias Abd Al-Kareem, Adam Abdelmonem A M, Gadallah Mohamed A, Ahmed Saad Mohamed Ali, Khyrallh Ahmed, Alsayed Mohammed H, Awad Esmail Tharwat Kamel, Ibrahim Emad A, Elshafey Mohammed Hassan, Labib Mohamed Fathy, Badawy Mahmoud Hassib Morsi, Teama Sobhy Rezk Ahmed, Seleem Abdelhafez, Abo Alsaad Mohamed Ibrahim, Ali Abouelatta Kh, Elbelkasi Hamdi, Abou Zaid Mahmoud Ali, Mohamed Basma Ahmed, Alwadees Alaa, El-Taher Ahmed K, Mansour Mohamed Ibrahim, Yassin Mahmoud Abdou, Arafa Ahmed Salah, Lotfy Mohamed, Atef Baher, Elnemr Mohamed, Khairy Mostafa M, Abdelwanis Abdelfatah H, Abdelaziz Ahmed Mesbah, Mostafa Abdelshafy, Hamed AbdElwahab M, Wasefy Tamer, Heggy Ibrahim A, Nawar Abdelrahman Mohamed Hasanin. COVID-19-specific risk factor for early post-appendectomy complications (EPAC) in older patients: a retrospective study.. Techniques in coloproctology. 2025. DOI: 10.1007/s10151-025-03232-1.

Предметные рубрики MeSH

Aged Aged, 80 and over Female Humans Male Middle Aged Age Factors Appendectomy Appendicitis COVID-19 Incidence Postoperative Complications Retrospective Studies Risk Factors SARS-CoV-2 Surgical Wound Infection

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