The Journal of emergency medicine · 2026
A Retrospective Study of the Respiratory Rate Oxygenation and Respiratory Rate Oxygenation-Heart Rate Indexes in Predicting the Results of Conventional Oxygen Therapy in Patients with Acute Respiratory Failure.
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Shen Jinyun, Fang Yang, You Hui, Li Jianping, Xu Xianan
Аннотация
BACKGROUND: Conventional oxygen therapy is a first-line treatment for acute respiratory failure, but accurately predicting which patients will require escalated respiratory support remains a critical clinical challenge.
OBJECTIVE: To explore the clinical significance of the respiratory rate oxygenation (ROX) and ROX-heart rate (ROX-HR) indexes in forecasting outcomes of standard oxygen therapy in patients with acute respiratory failure (ARF).
METHODS: This retrospective study analyzed 262 ARF patients admitted to the emergency department between June 2021 and May 2023. Patients were categorized into a Success group (n = 153) and a Failure group (n = 109) based on their response to standard oxygen therapy. ROX and ROX-HR indexes were compared between groups at baseline 0 h and 1 h, and we assessed the predictive efficacy by Receptor Operator Characteristic (ROC) curves, Area under the ROC curve (AUROC), and multivariable Logistic regression.
RESULTS: The Success group had significantly higher ROX and ROX-HR indexes at both 0 h and 1 h compared to the Failure group (all p < 0.001). At 0 h, the AUROC for the ROX-HR index outperformed the ROX index at 0.76 (95% CI 0.70-0.81), and 0.75 (95% CI 0.69-0.81) respectively. The ROX-HR-0 was found to be an independent predictor of successful response to oxygen therapy in a multivariate analysis (odds ratio [OR] = 0.48, 95% CI 0.27-0.86, p = 0.013).
CONCLUSIONS: The ROX and ROX-HR indexes were associated with the outcome of standard oxygen therapy in patients with ARF, with the ROX-HR index showing a good AUROC. Further validation in larger patient populations is warranted to confirm their utility as dynamic monitoring tools.
OBJECTIVE: To explore the clinical significance of the respiratory rate oxygenation (ROX) and ROX-heart rate (ROX-HR) indexes in forecasting outcomes of standard oxygen therapy in patients with acute respiratory failure (ARF).
METHODS: This retrospective study analyzed 262 ARF patients admitted to the emergency department between June 2021 and May 2023. Patients were categorized into a Success group (n = 153) and a Failure group (n = 109) based on their response to standard oxygen therapy. ROX and ROX-HR indexes were compared between groups at baseline 0 h and 1 h, and we assessed the predictive efficacy by Receptor Operator Characteristic (ROC) curves, Area under the ROC curve (AUROC), and multivariable Logistic regression.
RESULTS: The Success group had significantly higher ROX and ROX-HR indexes at both 0 h and 1 h compared to the Failure group (all p < 0.001). At 0 h, the AUROC for the ROX-HR index outperformed the ROX index at 0.76 (95% CI 0.70-0.81), and 0.75 (95% CI 0.69-0.81) respectively. The ROX-HR-0 was found to be an independent predictor of successful response to oxygen therapy in a multivariate analysis (odds ratio [OR] = 0.48, 95% CI 0.27-0.86, p = 0.013).
CONCLUSIONS: The ROX and ROX-HR indexes were associated with the outcome of standard oxygen therapy in patients with ARF, with the ROX-HR index showing a good AUROC. Further validation in larger patient populations is warranted to confirm their utility as dynamic monitoring tools.