Journal of the neurological sciences · 2026
Use of the inactivated SARS-CoV-2 vaccine and the risk of Bell's palsy in China: A case-control study.
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Zhang Tao, Du Heng, Wang Yifu, Gu Yue, Song Xiaoyan, Shen Yijue, Lu Haiyan, Fang Kan, Hu Qimin, Wang Qiaoshu, Wang Guodong
Аннотация
BACKGROUND: Bell's palsy has been suggested as a possible adverse event of the inactivated SARS-CoV-2 vaccine. The aim of this study is to examine the association between the inactivated SARS-CoV-2 vaccine and Bell's palsy.
METHODS: A large-scale muticenter case-control study carried out in two medical centers in Shanghai, China. We evaluated the risk of Bell's palsy after the inactivated SARS-CoV-2 vaccination. Patients with Bell's palsy admitted to the hospitals from February 1, 2021, to January 31, 2022 were recruited and controls were matched (1:2) by age, sex and admission date. Bell's palsy risk was evaluated as the proportion of patients exposed to the inactivated vaccine between groups using logistic regression to estimate the odds ratio (OR).
RESULTS: Seven hundred and ninety-three Bell's palsy patients were matched to 1586 controls. The excess of Bell's palsy occurred post-vaccination compared with the controls, and the adjusted OR for exposure was 1.208 (95 % CI, 1.009-1.446; P = 0.040). The risk of Bell's palsy was more pronounced after the first vaccine dose (adjusted OR 1.603, 95 % CI, 1.105-2.325, P = 0.013) and most of the vaccines (51/58, 88 %) were administered within 60 days prior to Bell's palsy.
INTERPRETATION: This study suggested that the inactivated SARS-CoV-2 vaccination is associated with an increased risk of Bell's palsy, and that this association appears to be more pronounced in patients after the first dose vaccination. However, potential residual confounding may exist in the study due to its retrospective nature.
METHODS: A large-scale muticenter case-control study carried out in two medical centers in Shanghai, China. We evaluated the risk of Bell's palsy after the inactivated SARS-CoV-2 vaccination. Patients with Bell's palsy admitted to the hospitals from February 1, 2021, to January 31, 2022 were recruited and controls were matched (1:2) by age, sex and admission date. Bell's palsy risk was evaluated as the proportion of patients exposed to the inactivated vaccine between groups using logistic regression to estimate the odds ratio (OR).
RESULTS: Seven hundred and ninety-three Bell's palsy patients were matched to 1586 controls. The excess of Bell's palsy occurred post-vaccination compared with the controls, and the adjusted OR for exposure was 1.208 (95 % CI, 1.009-1.446; P = 0.040). The risk of Bell's palsy was more pronounced after the first vaccine dose (adjusted OR 1.603, 95 % CI, 1.105-2.325, P = 0.013) and most of the vaccines (51/58, 88 %) were administered within 60 days prior to Bell's palsy.
INTERPRETATION: This study suggested that the inactivated SARS-CoV-2 vaccination is associated with an increased risk of Bell's palsy, and that this association appears to be more pronounced in patients after the first dose vaccination. However, potential residual confounding may exist in the study due to its retrospective nature.