Journal of the American Academy of Dermatology · 2025
Population differences in Merkel cell carcinoma by virus status and anatomic site: A multi-cohort analysis including institutional, SEER, and NCDB data.
СтатьяResearch Support, N.I.H., IntramuralНазвание и аннотация: Перевод в очереди
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Martin Mackenzie R, Vilasi Serena M, Saito Yoshine, Mohsin Noreen, Jarvis Jordan E, Hallaert Patrick, Reed Danielle J, Miao Lingling, Tribble Jacob T, Cahoon Elizabeth K, Pfeiffer Ruth M, Lachance Krista, Kulikauskas Rima, Nghiem Paul, Brownell Isaac
Аннотация
BACKGROUND: The impact of race/ethnicity on Merkel cell carcinoma (MCC) outcomes remains inconclusive.
OBJECTIVE: To examine associations between MCC primary site, virus status, environmental ultraviolet radiation (UVR), and race/ethnicity.
METHODS: Patients diagnosed with MCC at the University of Washington (UW), in Surveillance, Epidemiology, and End Results (SEER-17), in National Cancer Database (NCDB), and global incidence and virus status data were included in this retrospective multi-cohort study. We estimated the prognostic effect of virus status using a Cox proportional hazards model, conducted a pooled analysis of tumor site and virus status, and investigated racial/ethnic differences in site using SEER and NCDB. We also estimated global MCC viral subtype incidences and assessed their association with geographic UV indices.
RESULTS: Virus-positive MCC (VP-MCC) showed improved survival compared to virus-negative MCC (VN-MCC) (P < .001) and was more likely to develop on UV-protected skin (P < .001). Black and Hispanic patient tumors were more likely to present on UV-protected sites (P < .001). Globally, UVR had a bigger effect on VN-MCC incidence than VP-MCC.
LIMITATIONS: Nonstandardized virus assays, unknown patient migration histories, incomplete global data, and registry selection bias.
CONCLUSION: Black and Hispanic patients more often develop MCC on UV-protected sites, which are more likely VP-MCC and associated with improved outcomes.
OBJECTIVE: To examine associations between MCC primary site, virus status, environmental ultraviolet radiation (UVR), and race/ethnicity.
METHODS: Patients diagnosed with MCC at the University of Washington (UW), in Surveillance, Epidemiology, and End Results (SEER-17), in National Cancer Database (NCDB), and global incidence and virus status data were included in this retrospective multi-cohort study. We estimated the prognostic effect of virus status using a Cox proportional hazards model, conducted a pooled analysis of tumor site and virus status, and investigated racial/ethnic differences in site using SEER and NCDB. We also estimated global MCC viral subtype incidences and assessed their association with geographic UV indices.
RESULTS: Virus-positive MCC (VP-MCC) showed improved survival compared to virus-negative MCC (VN-MCC) (P < .001) and was more likely to develop on UV-protected skin (P < .001). Black and Hispanic patient tumors were more likely to present on UV-protected sites (P < .001). Globally, UVR had a bigger effect on VN-MCC incidence than VP-MCC.
LIMITATIONS: Nonstandardized virus assays, unknown patient migration histories, incomplete global data, and registry selection bias.
CONCLUSION: Black and Hispanic patients more often develop MCC on UV-protected sites, which are more likely VP-MCC and associated with improved outcomes.