Bioelectric Modulation as a Systems-Level Adjunct to Regenerative Therapies in Facial Plastic Surgery and Hair Restoration.

Regenerative strategies in facial plastic surgery increasingly incorporate platelet-rich fibrin, platelet-rich plasma, fat grafting, and emerging biologic agents. Despite widespread adoption, outcomes remain variable, in part due to limited control of upstream processes such as perfusion, extracellular matrix remodeling, and stem cell niche stability. To review the mechanistic basis and emerging clinical evidence supporting bioelectric modulation as a systems-level regulator of regenerative pathways relevant to facial rejuvenation, wound healing, and hair restoration. Bioelectric modulation represents a plausible investigational adjunct to biologic therapies in facial plastic surgery. Further studies are required to define efficacy, optimize treatment parameters, and evaluate long-term safety.