Nature communications · 2021
Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Lou Min-Min, Tang Xiao-Qiang, Wang Guang-Ming, He Jia, Luo Fang, Guan Ming-Feng, Wang Fei, Zou Huan, Wang Jun-Ying, Zhang Qun, Xu Ming-Jian, Shi Qi-Li, Shen Li-Bing, Ma Guo-Ming, Wu Yi, Zhang Yao-Yang, Liang Ai-Bin, Wang Ting-Hua, Xiong Liu-Lin, Wang Jian, Xu Jun, Wang Wen-Yuan
Аннотация
Long noncoding RNAs (lncRNAs) are known to regulate DNA damage response (DDR) and genome stability in proliferative cells. However, it remains unknown whether lncRNAs are involved in these vital biological processes in post-mitotic neurons. Here, we report and characterize a lncRNA, termed Brain Specific DNA-damage Related lncRNA1 (BS-DRL1), in the central nervous system. BS-DRL1 is a brain-specific lncRNA and depletion of BS-DRL1 in neurons leads to impaired DDR upon etoposide treatment in vitro. Mechanistically, BS-DRL1 interacts with HMGB1, a chromatin protein that is important for genome stability, and is essential for the assembly of HMGB1 on chromatin. BS-DRL1 mediated DDR exhibits cell-type specificity in the cortex and cerebellum in gamma-irradiated mice and BS-DRL1 knockout mice show impaired motor function and concomitant purkinje cell degeneration. Our study extends the understanding of lncRNAs in DDR and genome stability and implies a protective role of lncRNA against neurodegeneration.