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medRxiv : the preprint server for health sciences · 2026

Altered neurodevelopmental trajectories of brain structure in Tourette syndrome and Chronic Tic Disorders.

СтатьяПрепринтНазвание и аннотация: Перевод в очереди
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Jin Yin, Guo Yuxin, Koller Jonathan M, Grossen Sarah C, Uhlmann Anne, Forde Natalie J, Zouki Jade-Jocelyne, Torrecuso Renzo, Mueller Karsten, Martin-Rodriguez Juan F, Franco-Rosado Pablo, Grothe Michel, Cramer Catharina, Büning Anne Kleine, Eichele Heike, Palmucci Stefano, Prato Adriana, Saia Federica, Tommasin Silvia, Conte Giulia, Schindlbeck Katharina A, Ganos Christos, Zimmermann Shukti, Veselinovic Tanja, Worbe Yulia, Hartmann Andreas, Topaloudi Apostolia, Kaka Mary, Chen Guangxin, Zhong Qingyi, Zhang Yuqi, Szejko Natalia, Janik Piotr, Debes Nanette M, Tumer Zeynep, Wolańczyk Tomasz, Heiman Gary A, Stefansson Hreinn, Ask Helga, Andreassen Ole, Børglum Anders D, Buxbaum Joseph D, Corfield Elizabeth C, Daly Mark, Grice Dorothy E, Mataix-Cols David, Palotie Aarno, Rück Christian, Halvorsen Matthew W, Davis Lea K, Crowley James J, Mattheisen Manuel, Yu Dongmei, Mathews Carol A, Scharf Jeremiah M, members of the Tourette International TS-EUROTRAIN/TSGeneSEE, TAA Neuroimaging Consortium, Collaborative Genetics consortium, TAAICG, EMTICS, ENIGMA-TS Working Group, Stein Dan J, Neuner Irene, Musil Richard, Cardona Francesco, Cath Danielle, Veltman Dick J, Silk Tim J, Munchau Alexander, Verrel Julius, Brandt Valerie C, Hershey Tamara, Greene Deanna J, Schlaggar Bradley L, Buitelaar Jan, Franke Barbara, Thomopoulos Sophia, Rizzo Renata, Dietrich Andrea, Hoekstra Pieter J, Mir Pablo, Roessner Veit, van den Heuvel Odile A, Mueller-Vahl Kirsten, Möller Harald, Jahanshad Neda, Thompson Paul M, Black Kevin J, Paschou Peristera

Аннотация

Tourette syndrome (TS) is a neurodevelopmental disorder characterized by symptoms that emerge in childhood and often improve or even disappear in adulthood, providing a model for understanding how altered brain development shapes neural structure and function. We investigate brain structural alterations in TS and Chronic Tic Disorders (TS/CTD) across development, presenting the largest structural neuroimaging analysis for TS/CTD to date (1,803 individuals from the ENIGMA-TS Working Group), and integrating with large-scale genomewide association studies. Nonlinear age effects were observed in cortical thickness across development and in thalamic volume in children, indicating altered trajectories of brain maturation. Pediatric and adult TS/CTD showed distinct structural patterns, with widespread alterations in childhood and more focal changes in adulthood. Children also showed the most prominent effects highlighting the involvement of orbitofrontal cortex and putamen, alongside additional regions such as frontal and paralimbic areas. Genetic pleiotropy analyses identified overlap between TS/CTD-associated genetic effects on brain structure and neuroanatomical differences. Cross-disorder comparisons revealed correlations with ADHD and OCD and age-related patterns. These findings demonstrate altered neurodevelopmental trajectories in TS/CTD and implicate systems underlying inhibitory control and urge regulation.