A 72-Year-Old Man With Dyspnea, Weight Loss, and Recurrent Right-Sided Exudative Pleural Effusion.

A 72-year-old man with coronary artery disease, heart failure with preserved ejection fraction, smoldering multiple myeloma, treated latent TB, and Agent Orange exposure sought treatment for dyspnea, 10-lb weight loss over several months, and recurrent exudative pleural effusion. Outpatient workup included negative pleural fluid cytology and culture results. CT imaging showed diffuse mesenteric and retroperitoneal lymphadenopathy with mild PET imaging activity, but no cervical or thoracic lymphadenopathy. Thoracentesis had been performed 4 months previously, and again 1 week before admission, suggesting accelerated reaccumulation.