Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation · 2026
Determinants of Early Acute Kidney Injury After Liver Transplant: The Role of Liver Disease Severity.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ozer Suzan, Celebi Zeynep Kendi, Haberal Mehmet
Аннотация
OBJECTIVES: Acute kidney injury is a frequent complication after liver transplant and is associated with adverse patient and graft outcomes. This study aimed to identify preoperative, perioperative, and postoperative risk factors for early postoperative acute kidney injury in patients undergoing liver transplant for chronic liver disease.
MATERIALS AND METHODS: This retrospective, single -center cohort study included adult patients (≥18 years ) who underwent liver transplant between April 1998 and April 2023 at Baskent University Ankara Hospital. Patients having pretransplant end -stage renal disease and with less than 1 year of posttransplant follow -up were excluded. Acute kidney injury was defined according to the Kidney Disease: Improving Global Outcomes 2012 criteria. Pretransplant and posttransplant demographic, clinical, and laboratory data were analyzed.
RESULTS: The study included 179 patients followed for 120 ± 76 months (mean age, 43 ±14 years; 72 % male ). Early postoperative acute kidney injury occurred in 103 patients (57.5 % ). Patients with acute kidney injury had higher preoperative Child-Pugh and Model for End-Stage Liver Disease-Sodium (MELD -Na ) scores (both P < . ⁰⁰¹ ), a greater prevalence of ascites (P = . ⁰⁰³ ) and hepatorenal syndrome (P = . ⁰⁰⁷ ), and higher baseline serum creatinine levels (P < . ⁰⁰¹ ). Early postoperative infections (P < . ⁰⁰¹ ) and surgical complications (P = . ⁰⁰³ ) were also more frequent in the acute kidney injury group. In multivariate analysis, preoperative ascites, higher Model for End -Stage Liver Disease-Sodium scores, and lower preoperative low -density lipoprotein cholesterol levels were independently associated with early postoperative acute kidney injury.
CONCLUSIONS: The severity of underlying liver disease is the main determinant of early postoperative acute kidney injury after liver transplant. Optimization of reversible etiologic factors and careful perioperative hemodynamic management may reduce the risk.
MATERIALS AND METHODS: This retrospective, single -center cohort study included adult patients (≥18 years ) who underwent liver transplant between April 1998 and April 2023 at Baskent University Ankara Hospital. Patients having pretransplant end -stage renal disease and with less than 1 year of posttransplant follow -up were excluded. Acute kidney injury was defined according to the Kidney Disease: Improving Global Outcomes 2012 criteria. Pretransplant and posttransplant demographic, clinical, and laboratory data were analyzed.
RESULTS: The study included 179 patients followed for 120 ± 76 months (mean age, 43 ±14 years; 72 % male ). Early postoperative acute kidney injury occurred in 103 patients (57.5 % ). Patients with acute kidney injury had higher preoperative Child-Pugh and Model for End-Stage Liver Disease-Sodium (MELD -Na ) scores (both P < . ⁰⁰¹ ), a greater prevalence of ascites (P = . ⁰⁰³ ) and hepatorenal syndrome (P = . ⁰⁰⁷ ), and higher baseline serum creatinine levels (P < . ⁰⁰¹ ). Early postoperative infections (P < . ⁰⁰¹ ) and surgical complications (P = . ⁰⁰³ ) were also more frequent in the acute kidney injury group. In multivariate analysis, preoperative ascites, higher Model for End -Stage Liver Disease-Sodium scores, and lower preoperative low -density lipoprotein cholesterol levels were independently associated with early postoperative acute kidney injury.
CONCLUSIONS: The severity of underlying liver disease is the main determinant of early postoperative acute kidney injury after liver transplant. Optimization of reversible etiologic factors and careful perioperative hemodynamic management may reduce the risk.