Human parvovirus B19 (B19V) is an ubiquitously spread, exclusively human pathogen, mainly posing risks to children, as well as pregnant and immunocompromised individuals. Despite evidence of B19V infection of human populations as far back as 7,000 years, the evolutionary history of B19V remains poorly understood. In this study, we present B19V genomic data from the remains of 53 globally distributed individuals spanning more than 8,000 years, including 7 children. Our findings suggest that the most recent common ancestor of all present B19V lineages existed around 12,000 years ago, at the end of the last Ice Age. Additionally, we identified an extinct Eurasian clade that participated in the recombination event that led to the emergence of B19V genotype 2 (GT-2). We date this event to ∼3,200-1,800 BP, potentially in the greater Mediterranean area. Our study shows aspects of how ancient parvovirus variants arose, disseminated, and impacted human health through time.
Для цитирования: Zeibig Teresa, Spyrou Maria A, Kocher Arthur, Gaul Emily, Aldenderfer Mark, Barquera Rodrigo, Beckett Jessica F, Beisenov Arman, Belinski Andrey B, Betancourt Philip P, Boersma Ruth, Carrion Pablo, Childebayeva Ainash, Cooper Christine, Cucca Francesco, Di Salvo Rosaria, Dizdar Marko, Djansugurova Leyla, Ernée Michal, Ferrence Susan C, Fehren-Schmitz Lars, Ghalichi Ayshin, Giffin Karen L, Gilbert Steven, Gómez-Valdés Jorge A, Gretzinger Joscha, Hansen Leif, Hansen Svend, Hernandez-Zaragoza Diana Iraiz, Jankauskas Rimantas, Jeong Choongwon, Keller Marcel, Khartanovich Valery, Kim Daewook, Kinaston Rebecca, Kovalev Alexey, Kozakaitė Justina, Krausse Dirk, Krznar Siniša, Küßner Mario, Langford Louise C, Lai Luca, Lösch Sandra, Majander Kerttu, Mannino Marcello A, Márquez-Morfín Lourdes, McCormick Michael, McGeorge Photini J P, Michel Megan, Moiseyev Vyacheslav, Moon Hyoungmin, Mötsch Angela, Musralina Lyazzat, Myagmar Erdene, Nakoro Elia, Németh Rita E, Neumann Gunnar U, Novak Mario, Olmo Enciso Lauro, Onkamo Päivi, Papac Luka, Peltola Sanni, Posth Cosimo, Powell Adam, Radimilahy Chantal, Rajković Dragana, Rakotoarisoa Jean-Aimé, Rasoarifetra Bako Nirina, Reinhold Sabine, Risch Roberto, Samashev Zainolla, Sayer Duncan, Schimmenti Vittoria, Schmitt Felicitas, Sintes Elena, Slavin Philip, Sorokin Denis, Terberger Thomas, Tukhbatova Rezeda, Vågene Åshild J, Van de Vijver Katrien, Vigil-Escalera Guirado Alfonso, Villalba-Mouco Vanessa, Voyakin Dmitriy, Woo Eun Jin, Ximenez Teresa, Stockhammer Philipp, Warinner Christina, Bos Kirsten, Schiffels Stephan, Mittnik Alissa, Haak Wolfgang, Herbig Alexander, Krause Johannes. Tracing the evolution and diversity of human parvovirus B19 across human history.. Current biology : CB. 2026. DOI: 10.1016/j.cub.2026.08.032.
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