Nature · 2025
Deciphering phenylalanine-derived salicylic acid biosynthesis in plants.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Wang Yukang, Song Shuyan, Zhang Wenxuan, Deng Qianwen, Feng Yanlei, Tao Mei, Kang Mengna, Zhang Qi, Yang Lijia, Wang Xinyu, Zhu Changan, Wang Xiaowen, Zhu Wanxin, Zhu Yixiao, Cao Pengfei, Chen Jia, Pan Jinheng, Feng Shan, Chen Xianyan, Dai Huaxin, Song Shiyong, Yang Jinghua, Zhao Tianlun, Cao Fangbin, Tao Zeng, Shen Xingxing, Last Robert L, Hu Jianping, Yu Jingquan, Fan Pengxiang, Pan Ronghui
Аннотация
Salicylic acid (SA) is a ubiquitous plant hormone with a long history in human civilization1,2. Because of the central role of SA in orchestrating plant pathogen defence, understanding SA biosynthesis is fundamental to plant immunity research and crop improvement. Isochorismate-derived SA biosynthesis has been well defined in Arabidopsis. However, increasing evidence suggests a crucial function for phenylalanine-derived SA biosynthesis in many other plant species1. Here we reveal the phenylalanine-derived SA biosynthetic pathway in rice by identifying three dedicated enzymes - peroxisomal benzoyl-CoA:benzyl alcohol benzoyltransferase (BEBT), the endoplasmic reticulum-associated cytochrome P450 enzyme benzylbenzoate hydroxylase (BBH), and cytosolic benzylsalicylate esterase (BSE) that sequentially convert benzoyl-CoA to benzylbenzoate, benzylsalicylate and SA. The pathogen-induced gene expression pattern and SA biosynthetic functions of this triple-enzyme module are conserved in diverse plants. This work fills a major knowledge gap in the biosynthesis of a key plant defence hormone, establishing a foundation for new strategies to create disease-resistant crops.