Metabolic signatures in metabolic dysfunction-associated steatotic liver disease-related hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a common and lethal malignancy, with an increasing incidence globally, which is partially attributed to the rising prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD). Complex metabolic rearrangements occur in MASLD-related HCC (MASLD-HCC) to promote the initiation and development of cancer. Nevertheless, comprehensive understanding of the metabolic transformations during the progression from MASLD to HCC remains limited. In this review, we introduce recent advances characterizing the metabolic changes in MASLD-HCC, thereby offering potential directions and clues for further studies.