Mature T/NK-Cell lymphomas of the oral and maxillofacial region: A multi-institutional collaborative study.
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de Arruda José Alcides Almeida, Abrantes Thamiris de Castro, Cunha John Lennon Silva, Roza Ana Luiza Oliveira Corrêa, Agostini Michelle, Abrahão Aline Corrêa, Canedo Nathalie Henriques Silva, Ramos Denize D'Azambuja, Milito Cristiane Bedran, Pontes Flávia Sirotheau Correa, Pontes Hélder Antônio Rebelo, Barra Marinez Bizarro, Zanella Virgilio Gonzales, Martins Marco Antonio Trevizani, Martins Manoela Domingues, Israel Mônica Simões, Freire Nathália de Almeida, Barreto Maria Eduarda Zeraik, Sánchez-Romero Celeste, Carlos Román, Abreu Lucas Guimarães, Vargas Pablo Agustin, de Almeida Oslei Paes, Fonseca Felipe Paiva, Romañach Mário José, Mesquita Ricardo Alves, de Andrade Bruno Augusto Benevenuto
Аннотация
METHODS: Cases diagnosed as mature T/NK-cell lymphomas affecting the oral and maxillofacial region were retrospectively retrieved from six pathology files and their diagnoses were confirmed using haematoxylin and eosin-stained slides, immunohistochemical reactions and in situ hybridization for Epstein-Barr virus (EBV) detection. Patients' clinical data were collected from their pathology forms.
RESULTS: A total of 22 cases were included in this study. Eleven (50%) consisted of extranodal NK/T-cell lymphomas, nasal type; eight (36.4%) were peripheral T-cell lymphomas, NOS; two (9.1%) were adult T-cell leukaemia/lymphomas, and one (4.5%) was an ALK-positive anaplastic large cell lymphoma. Overall, males predominated, with a mean age of 55.7 years. The palate was the most affected site (50%), and tumours usually presented as destructive and painful ulcers. EBV was present in all cases of extranodal NK/T-cell lymphoma nasal type but was absent in the other subtypes.
CONCLUSION: Among mature T/NK-cell lymphomas of the oral and maxillofacial region, extranodal NK/T-cell lymphoma, nasal type and peripheral T-cell lymphoma, NOS predominated. Older men were the most affected patients, and this heterogeneous group of neoplasms has a very aggressive clinical behaviour.