JACC. Case reports · 2026
Clinical Heterogeneity of Recurrent Familial Cardiac Myxoma in PRKAR1A-Related Carney Complex.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Vallejos Barrientos Alexis, Espinoza Alva Daniel, Davila Flores Diego, Montesinos Segura Renee, Aguilar Carranza Cristian, Zamudio Silva Romel
Аннотация
BACKGROUND: Cardiac myxomas are common benign primary cardiac tumors; hereditary forms are strongly associated with the Carney complex.
CASE SUMMARY: A 42-year-old woman with familial Carney complex and a pathogenic PRKAR1A variant developed recurrent cardiac myxomas involving 3 of the 4 chambers. The first presentation featured left atrial and right ventricular myxomas causing cardioembolic cerebellar stroke. A first recurrence in the left atrium caused severe transmitral obstruction and decompensated heart failure. A second recurrence in the right atrium presented as an infected myxoma. A third recurrence arose from the tricuspid annulus 4 months after resection; because further reoperation after 2 prior sternotomies and a right thoracotomy was considered prohibitive, she was listed for transplantation but died suddenly while awaiting transplant.
DISCUSSION: This case highlights the aggressive, recurrent, and clinically heterogeneous phenotype and fatal course of Carney complex-associated cardiac myxoma.
TAKE-HOME MESSAGE: Early recognition, lifelong surveillance, and timely consideration of advanced strategies are essential in selected patients with recurrent disease.
CASE SUMMARY: A 42-year-old woman with familial Carney complex and a pathogenic PRKAR1A variant developed recurrent cardiac myxomas involving 3 of the 4 chambers. The first presentation featured left atrial and right ventricular myxomas causing cardioembolic cerebellar stroke. A first recurrence in the left atrium caused severe transmitral obstruction and decompensated heart failure. A second recurrence in the right atrium presented as an infected myxoma. A third recurrence arose from the tricuspid annulus 4 months after resection; because further reoperation after 2 prior sternotomies and a right thoracotomy was considered prohibitive, she was listed for transplantation but died suddenly while awaiting transplant.
DISCUSSION: This case highlights the aggressive, recurrent, and clinically heterogeneous phenotype and fatal course of Carney complex-associated cardiac myxoma.
TAKE-HOME MESSAGE: Early recognition, lifelong surveillance, and timely consideration of advanced strategies are essential in selected patients with recurrent disease.