World journal of gastrointestinal surgery · 2026
Gallbladder small cell carcinoma from chronic cholecystitis: A case report and review of literature.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Yu Jia-Qi, He Xue-Song, Xue Yu-Zhe, Hu Ling-Yu, Wen Xu, Yang Xiao-Dan, Zhou Xue
Аннотация
BACKGROUND: Chronic calculous cholecystitis (CCC), caused by persistent gallstone-induced inflammation, can lead to development of small cell neuroendocrine carcinoma (SCNEC) of the gallbladder through chronic irritation, cellular damage, and repair. This report describes a rare case of advanced SCNEC of the gallbladder potentially induced by CCC and highlights its clinical features and treatment challenges.
CASE SUMMARY: A 64-year-old woman with a history of CCC presented with persistent right upper quadrant pain. Imaging revealed a mass in the gallbladder and hepatic hilum. The patient underwent radical cholecystectomy and hepatic resection. Histopathological examination confirmed SCNEC with synaptophysin and CD56 positivity and Ki-67 of 80%. Due to severe hepatic dysfunction (total bilirubin ≥ 300 μmol/L, albumin ≤ 25 g/L), chemotherapy was contraindicated. The patient's condition deteriorated rapidly, and she died 2 months postoperatively.
CONCLUSION: Early detection and surgical intervention are critical for improving outcomes in gallbladder SCNEC associated with chronic inflammation.
CASE SUMMARY: A 64-year-old woman with a history of CCC presented with persistent right upper quadrant pain. Imaging revealed a mass in the gallbladder and hepatic hilum. The patient underwent radical cholecystectomy and hepatic resection. Histopathological examination confirmed SCNEC with synaptophysin and CD56 positivity and Ki-67 of 80%. Due to severe hepatic dysfunction (total bilirubin ≥ 300 μmol/L, albumin ≤ 25 g/L), chemotherapy was contraindicated. The patient's condition deteriorated rapidly, and she died 2 months postoperatively.
CONCLUSION: Early detection and surgical intervention are critical for improving outcomes in gallbladder SCNEC associated with chronic inflammation.