Retina (Philadelphia, Pa.) · 2026
INNER FOVEAL IRREGULARITIES AFTER VITREOMACULAR DETACHMENT: A Morphologic Risk Factor for Macular Hole Formation in the Fellow Eye.
СтатьяНазвание и аннотация: Перевод в очереди
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Klaas Julian E, Siedlecki Jakob, Vogt Denise, Schworm Benedikt, Hagenau Felix, Keidel Leonie, Bleidißel Nathalie, Maier Mathias, Priglinger Siegfried
Аннотация
PURPOSE: To assess the morphologic risk of full-thickness macular hole (FTMH) formation in the fellow eye based on posterior vitreous detachment (PVD) status and preceding vitreomacular interface changes using optical coherence tomography data of the fellow eye.
METHODS: The natural history of fellow eyes of patients with unilateral FTMH was reviewed for tractional maculopathies, symmetry of the foveal contour, inner and outer retinal irregularities, and PVD status on spectral domain optical coherence tomography. Posterior vitreous detachment was classified as incomplete (incomplete PVD = vitreomacular adhesion or traction) or macular (mPVD = vitreomacular detachment). Foveal contour changes were classified as inner foveal irregularity (IFI) if mPVD was present without evidence of other tractional maculopathies.
RESULTS: Seventy-two eyes of 72 consecutive patients were included. Nine (12.5%) developed FTMH during a mean follow-up of 19.1 ± 23.8 (range: 3.0-133.0) months. Incomplete PVD at baseline was not associated with a higher incidence of FTMH at follow-up (10.5% mPVD vs. 14.7% incomplete PVD, P = 0.727). Nine of 38 eyes (23.7%) with mPVD had inner foveal irregularity at baseline. Inner foveal irregularity was a risk factor for FTMH formation after mPVD ( P = 0.033, OR = 14.0). The cumulative risk of IFI-FTMH conversion was 16.7% at 12 months and 44.4% at 24 months.
CONCLUSION: Inner foveal irregularity can be frequently documented in the fellow eyes of patients with FTMH and may be an early morphologic risk factor for FTMH formation after mPVD in the context of previous fellow eye involvement.
METHODS: The natural history of fellow eyes of patients with unilateral FTMH was reviewed for tractional maculopathies, symmetry of the foveal contour, inner and outer retinal irregularities, and PVD status on spectral domain optical coherence tomography. Posterior vitreous detachment was classified as incomplete (incomplete PVD = vitreomacular adhesion or traction) or macular (mPVD = vitreomacular detachment). Foveal contour changes were classified as inner foveal irregularity (IFI) if mPVD was present without evidence of other tractional maculopathies.
RESULTS: Seventy-two eyes of 72 consecutive patients were included. Nine (12.5%) developed FTMH during a mean follow-up of 19.1 ± 23.8 (range: 3.0-133.0) months. Incomplete PVD at baseline was not associated with a higher incidence of FTMH at follow-up (10.5% mPVD vs. 14.7% incomplete PVD, P = 0.727). Nine of 38 eyes (23.7%) with mPVD had inner foveal irregularity at baseline. Inner foveal irregularity was a risk factor for FTMH formation after mPVD ( P = 0.033, OR = 14.0). The cumulative risk of IFI-FTMH conversion was 16.7% at 12 months and 44.4% at 24 months.
CONCLUSION: Inner foveal irregularity can be frequently documented in the fellow eyes of patients with FTMH and may be an early morphologic risk factor for FTMH formation after mPVD in the context of previous fellow eye involvement.