Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2016
Bone mineral density measurements in otosclerosis using dual-energy X-ray absorptiometry.
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Tonuk S B, Koybasi S, Bicer Y O, Alkan Temel S
Аннотация
OBJECTIVES: This study aims to evaluate patients with otosclerosis with respect to bone mineral density (BMD) at different regions of interest (ROI), using dual-energy X-ray absorptiometry (DXA).
DESIGN: Cross-sectional controlled study.
SETTING: Tertiary referral hospital.
PARTICIPANTS: The patients with a definite diagnosis of otosclerosis confirmed intra-operatively were defined as the study group (n = 30). The control group consisted of volunteer, healthy subjects with normal hearing (n = 43).
MAIN OUTCOME MEASURES: Following an audiometric evaluation, a venous blood sample was obtained and a single BMD measurement using DXA was applied to each participant.
RESULTS: The mean BMD, T and Z scores were higher in the otosclerosis group than in the control group in all the regions considered, but not significantly; only the L2-L3 lateral BMD and its T and Z scores were significant (P = 0.036, P = 0.029 and P = 0.036, respectively).
CONCLUSION: This study shows that the BMD does not decrease in the presence of otosclerosis despite its genetic and metabolic relevance with osteoporosis. Concerning the L2-L3 lateral BMD measurements, the BMD increased in otosclerosis.
DESIGN: Cross-sectional controlled study.
SETTING: Tertiary referral hospital.
PARTICIPANTS: The patients with a definite diagnosis of otosclerosis confirmed intra-operatively were defined as the study group (n = 30). The control group consisted of volunteer, healthy subjects with normal hearing (n = 43).
MAIN OUTCOME MEASURES: Following an audiometric evaluation, a venous blood sample was obtained and a single BMD measurement using DXA was applied to each participant.
RESULTS: The mean BMD, T and Z scores were higher in the otosclerosis group than in the control group in all the regions considered, but not significantly; only the L2-L3 lateral BMD and its T and Z scores were significant (P = 0.036, P = 0.029 and P = 0.036, respectively).
CONCLUSION: This study shows that the BMD does not decrease in the presence of otosclerosis despite its genetic and metabolic relevance with osteoporosis. Concerning the L2-L3 lateral BMD measurements, the BMD increased in otosclerosis.