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DOI 10.1007/s10096-026-05640-z

Медицинская библиотека · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026

Moraxella species isolated from blood cultures in Europe (MORAXEu): a multicentre study of epidemiology and antimicrobial susceptibility with complementary phylogenomic analysis of publicly available genomes.

Tønjum Tone, da Silva Franklin-Duarte Vinicius, Berild Johan Christian, Gartzonika Konstantina, Christaki Eirini, Mavromanolaki Viktoria Eirini, Maraki Sofia, Spiliopoulou Anastasia, Giormezis Nikolaos, Lengerova Gergana, Kalchev Yordan, Budimir Ana, Bedenić Branka, Rubic Zana, Antonija Saskor, Milanovic Karla, Licker Monica, Musuroi Corina, Pirs Mateja, Velimirovic Ivana, Berktold Michael, Krajčíková Adriána, Gryndlerova Anezka, Drevinek Pavel, Sedláková Miroslava Htoutou, Kolář Milan, Brzychczy-Wloch Monika, Olechowska-Jarząb Aldona, Brauncajs Małgorzata, Bielec Filip, Seliga-Gąsior Dominika, Podsiadly Edyta, Riesbeck Kristian, Andersson Hanna-Sofia, Bastos Paulo, Leegaard Truls Michael, Nellemann Rasmussen Asger, Schønning Kristian, Glöckner Stefan, Rödel Jürgen, Posadas-Cantera Sara, Badr Mohamed Tarek, Kintzinger Tim, Schaumburg Frieder, Thelen Philipp, Hamprecht Axel, Dudakova Anna, Jantsch Jonathan, Hoffmann Katharina, Kaasch Achim J, Jacot Damien, Greub Gilbert, Landi Jessica, Ambretti Simone, Comini Sara, Chiatamone Ranieri Sofia, Serretiello Enrica, Franci Gianluigi, Fasciana Teresa, Schade Rogier, Yusuf Erlangga, van Kleef-van Koeveringe Stefanie, Vandamme Sarah, Verroken Alexia, Rodriguez-Villalobos Hector, Strubbe Gregory, Vandendriessche Stien, Rabeau Pauline, Corvec Stéphane, Dubois Damien, Floch Pauline, Chainier Delphine, Barraud Olivier, Mizrahi Assaf, Bacho Célia, Bouchiat Coralie, Fatah Tayssir, Marchandin Hélène, Jean-Pierre Vincent, Ali Saied, O'Donnell Sinead, Doyle Maeve, Ramsamaroo Zachary, Egan Clarice, McNicholas Sinead, Helgason Kristján Orri, Öngen Betigül, Karapınar Bahar Akgün, Oyardı Özlem, Aksu Burak, Colomina-Rodriguez Javier, Torres Ignacio, Gilarranz Luengo Raul, Larrosa Escartín Maria Nieves, Viñado Perez Maria Belen, Halperin Ana Verónica, Cantón Rafael, Seruca Miguel, Santos Mendes Vasco, Volovetska Yuliya, Melo Cristino José, Bianco Gabriele, Costa Cristina, Boattini Matteo

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Аннотация

INTRODUCTION

Moraxella species are fastidious Gram-negative bacteria capable of causing opportunistic infections, including bloodstream infections, especially in immunocompromised patients. Data on their epidemiology, antimicrobial susceptibility, and phylogenomics in Europe remains limited.

METHODS

We conducted a multicentre, retrospective, observational study across 56 European hospital centres between January 1st 2020 and December 31st 2024. All Moraxella species isolated from blood cultures (BCs) were included. Species distribution and antimicrobial susceptibility profiles were analysed. We also performed a phylogenomic analysis of Moraxella genomes deposited in GenBank.

RESULTS

A total of 709 Moraxella isolates were included. Moraxella osloensis (61.1%; n = 433/709) and Moraxella catarrhalis (20.4%; n = 145/709) were the most frequently identified species, followed by Moraxella nonliquefaciens (6.5%; n = 46/709) and Moraxella atlantae (4.8%; n = 34/709). Species distribution differed by age. M. catarrhalis was predominant in paediatric patients, whereas M. atlantae was more common in adults. Most isolates showed > 90% susceptibility to amoxicillin/clavulanate, cefotaxime, fluoroquinolones, and trimethoprim/sulfamethoxazole. Cefotaxime resistance in M. osloensis was more frequent in adults than in children (49% vs. 8%, p = 0.009). Phylogenomic analysis demonstrated the distinction of a core Moraxella group from the divergent Faucicola lineage, with M. osloensis and M. atlantae clustering within the latter.

CONCLUSIONS

The epidemiology of Moraxella species from BCs in Europe showed age-group-specific differences in species distribution and generally favourable antimicrobial susceptibility patterns. Phylogenomic data corroborated recent taxonomic revisions, highlighting the need for improved diagnostics, harmonized nomenclature and sustained surveillance to inform management and stewardship of Moraxella bacteraemia.

Для цитирования: Tønjum Tone, da Silva Franklin-Duarte Vinicius, Berild Johan Christian, Gartzonika Konstantina, Christaki Eirini, Mavromanolaki Viktoria Eirini, Maraki Sofia, Spiliopoulou Anastasia, Giormezis Nikolaos, Lengerova Gergana, Kalchev Yordan, Budimir Ana, Bedenić Branka, Rubic Zana, Antonija Saskor, Milanovic Karla, Licker Monica, Musuroi Corina, Pirs Mateja, Velimirovic Ivana, Berktold Michael, Krajčíková Adriána, Gryndlerova Anezka, Drevinek Pavel, Sedláková Miroslava Htoutou, Kolář Milan, Brzychczy-Wloch Monika, Olechowska-Jarząb Aldona, Brauncajs Małgorzata, Bielec Filip, Seliga-Gąsior Dominika, Podsiadly Edyta, Riesbeck Kristian, Andersson Hanna-Sofia, Bastos Paulo, Leegaard Truls Michael, Nellemann Rasmussen Asger, Schønning Kristian, Glöckner Stefan, Rödel Jürgen, Posadas-Cantera Sara, Badr Mohamed Tarek, Kintzinger Tim, Schaumburg Frieder, Thelen Philipp, Hamprecht Axel, Dudakova Anna, Jantsch Jonathan, Hoffmann Katharina, Kaasch Achim J, Jacot Damien, Greub Gilbert, Landi Jessica, Ambretti Simone, Comini Sara, Chiatamone Ranieri Sofia, Serretiello Enrica, Franci Gianluigi, Fasciana Teresa, Schade Rogier, Yusuf Erlangga, van Kleef-van Koeveringe Stefanie, Vandamme Sarah, Verroken Alexia, Rodriguez-Villalobos Hector, Strubbe Gregory, Vandendriessche Stien, Rabeau Pauline, Corvec Stéphane, Dubois Damien, Floch Pauline, Chainier Delphine, Barraud Olivier, Mizrahi Assaf, Bacho Célia, Bouchiat Coralie, Fatah Tayssir, Marchandin Hélène, Jean-Pierre Vincent, Ali Saied, O'Donnell Sinead, Doyle Maeve, Ramsamaroo Zachary, Egan Clarice, McNicholas Sinead, Helgason Kristján Orri, Öngen Betigül, Karapınar Bahar Akgün, Oyardı Özlem, Aksu Burak, Colomina-Rodriguez Javier, Torres Ignacio, Gilarranz Luengo Raul, Larrosa Escartín Maria Nieves, Viñado Perez Maria Belen, Halperin Ana Verónica, Cantón Rafael, Seruca Miguel, Santos Mendes Vasco, Volovetska Yuliya, Melo Cristino José, Bianco Gabriele, Costa Cristina, Boattini Matteo. Moraxella species isolated from blood cultures in Europe (MORAXEu): a multicentre study of epidemiology and antimicrobial susceptibility with complementary phylogenomic analysis of publicly available genomes.. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2026. DOI: 10.1007/s10096-026-05640-z.
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