Case reports in oncology · 2026
Transformation of Castleman Disease into Angioimmunoblastic T-Cell Lymphoma Complicated by Hemophagocytic Lymphohistiocytosis: A Case Report and Literature Review.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Meng Guangqiang, Yang Min, Liu Qian, Wang Yan, Feng Saran
Аннотация
INTRODUCTION: Castleman disease (CD) is a disease characterized by chronic lymphoid reactive hyperplasia. CD transforming into angioimmunoblastic T-cell lymphoma (AITL) complicated by hemophagocytic lymphohistiocytosis (HLH) is a rare and fatal disease with rapid progression, poor treatment, and poor prognosis.
CASE PRESENTATION: We present a case of idiopathic multicentric CD-transformed AITL complicated by HLH that achieved good therapeutic outcomes after treatment with ruxolitinib combined with CHOP regimen. The Epstein-Barr virus (EBV) in the peripheral blood of this patient remained positive throughout the course of the disease.
CONCLUSION: EBV could be involved in the mechanism of CD transforming into AITL complicated with HLH. Ruxolitinib combined with CHOP regimen may be a potentially effective treatment for this disease.
CASE PRESENTATION: We present a case of idiopathic multicentric CD-transformed AITL complicated by HLH that achieved good therapeutic outcomes after treatment with ruxolitinib combined with CHOP regimen. The Epstein-Barr virus (EBV) in the peripheral blood of this patient remained positive throughout the course of the disease.
CONCLUSION: EBV could be involved in the mechanism of CD transforming into AITL complicated with HLH. Ruxolitinib combined with CHOP regimen may be a potentially effective treatment for this disease.