Cureus · 2025
A Case Report of Combined Type 2 Autoimmune Hepatitis and Antiphospholipid Syndrome Presenting With Intracranial Hemorrhage: Diagnostic and Therapeutic Dilemma.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Mandal Shatabhisha, Panda Chittaranjan, Singh Harpreet, Anand Nidhi, Kumar Suresh
Аннотация
BACKGROUND: Autoimmune hepatitis (AIH) is very frequently associated with many autoimmune diseases. Antiphospholipid syndrome (APS) is frequently associated with type 1 AIH but rarely seen in type 2 AIH patients. In this case, the association between type 2 AIH and APS is seen, along with complications, which made the management difficult.
CASE PRESENTATION: This patient, who had a history of recurrent abortions, presented with complaints of recurrent epistaxis with severe thrombocytopenia. She was diagnosed with APS with concomitant type 2 AIH. After failing with conservative treatment, partial splenic artery embolization (PSAE) for recurrent thrombocytopenia was done, which led to improvement in platelet count and the resolution of recurrent epistaxis. But after a few days, the patient developed an intracranial hemorrhage (ICH) with a normal platelet count and coagulation profile. A platelet function study was done, and platelet dysfunction was found. Finally, after a prolonged period of admission, the patient developed sepsis and disseminated intravascular coagulation (DIC) and succumbed to death.
CONCLUSION: From this case, it may be kept in mind the possibility of the association of both types of AIH when dealing with a patient with APS. Unconventional methods such as partial splenic artery embolization can be useful in patients with recurrent thrombocytopenia. A platelet function study is a very important parameter to look for whenever a patient has bleeding with a normal coagulation profile and platelet count with isolated raised activated partial thromboplastin time (aPTT).
CASE PRESENTATION: This patient, who had a history of recurrent abortions, presented with complaints of recurrent epistaxis with severe thrombocytopenia. She was diagnosed with APS with concomitant type 2 AIH. After failing with conservative treatment, partial splenic artery embolization (PSAE) for recurrent thrombocytopenia was done, which led to improvement in platelet count and the resolution of recurrent epistaxis. But after a few days, the patient developed an intracranial hemorrhage (ICH) with a normal platelet count and coagulation profile. A platelet function study was done, and platelet dysfunction was found. Finally, after a prolonged period of admission, the patient developed sepsis and disseminated intravascular coagulation (DIC) and succumbed to death.
CONCLUSION: From this case, it may be kept in mind the possibility of the association of both types of AIH when dealing with a patient with APS. Unconventional methods such as partial splenic artery embolization can be useful in patients with recurrent thrombocytopenia. A platelet function study is a very important parameter to look for whenever a patient has bleeding with a normal coagulation profile and platelet count with isolated raised activated partial thromboplastin time (aPTT).