Oncology · 2013
Non-lymphoma hematological malignancies in systemic lupus erythematosus.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Lu Mary, Bernatsky Sasha, Ramsey-Goldman Rosalind, Petri Michelle, Manzi Susan, Urowitz Murray B, Gladman Dafna, Fortin Paul R, Ginzler Ellen M, Yelin Edward, Bae Sang-Cheol, Wallace Daniel J, Jacobsen Soren, Dooley Mary Anne, Peschken Christine A, Alarcón Graciela S, Nived Ola, Gottesman Lena, Criswell Lindsey A, Sturfelt Gunnar, Dreyer Lene, Lee Jennifer L, Clarke Ann E
Аннотация
OBJECTIVE: To describe non-lymphoma hematological malignancies in systemic lupus erythematosus (SLE).
METHODS: A large SLE cohort was linked to cancer registries. We examined the types of non-lymphoma hematological cancers.
RESULTS: In 16,409 patients, 115 hematological cancers [including myelodysplastic syndrome (MDS)] occurred. Among these, 33 were non-lymphoma. Of the 33 non-lymphoma cases, 13 were of lymphoid lineage: multiple myeloma (n = 5), plasmacytoma (n = 3), B cell chronic lymphocytic leukemia (B-CLL; n = 3), precursor cell lymphoblastic leukemia (n = 1) and unspecified lymphoid leukemia (n = 1). The remaining 20 cases were of myeloid lineage: MDS (n = 7), acute myeloid leukemia (AML; n = 7), chronic myeloid leukemia (CML; n = 2) and 4 unspecified leukemias. Most of these malignancies occurred in female Caucasians, except for plasma cell neoplasms (4/5 multiple myeloma and 1/3 plasmacytoma cases occurred in blacks).
CONCLUSIONS: In this large SLE cohort, the most common non-lymphoma hematological malignancies were myeloid types (MDS and AML). This is in contrast to the general population, where lymphoid types are 1.7 times more common than myeloid non-lymphoma hematological malignancies. Most (80%) multiple myeloma cases occurred in blacks; this requires further investigation.
METHODS: A large SLE cohort was linked to cancer registries. We examined the types of non-lymphoma hematological cancers.
RESULTS: In 16,409 patients, 115 hematological cancers [including myelodysplastic syndrome (MDS)] occurred. Among these, 33 were non-lymphoma. Of the 33 non-lymphoma cases, 13 were of lymphoid lineage: multiple myeloma (n = 5), plasmacytoma (n = 3), B cell chronic lymphocytic leukemia (B-CLL; n = 3), precursor cell lymphoblastic leukemia (n = 1) and unspecified lymphoid leukemia (n = 1). The remaining 20 cases were of myeloid lineage: MDS (n = 7), acute myeloid leukemia (AML; n = 7), chronic myeloid leukemia (CML; n = 2) and 4 unspecified leukemias. Most of these malignancies occurred in female Caucasians, except for plasma cell neoplasms (4/5 multiple myeloma and 1/3 plasmacytoma cases occurred in blacks).
CONCLUSIONS: In this large SLE cohort, the most common non-lymphoma hematological malignancies were myeloid types (MDS and AML). This is in contrast to the general population, where lymphoid types are 1.7 times more common than myeloid non-lymphoma hematological malignancies. Most (80%) multiple myeloma cases occurred in blacks; this requires further investigation.