International ophthalmology · 2026
Impact of prostaglandin-related antiglaucoma medication use on levator aponeurosis advancement outcomes.
СтатьяНазвание и аннотация: Перевод в очереди
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Ono Takashi, Matsuda Hitomi, Matsushima Kota, Ota Mami, Akiyama Reina, Shirakawa Rika, Toyono Tetsuya, Noda Mika, Honjo Megumi, Miyai Takashi
Аннотация
PURPOSE: To evaluate postoperative eyelid height at 3 months after levator aponeurosis advancement with or without concomitant skin excision in eyes with and without prostaglandin-related antiglaucoma medication use.
METHODS: This retrospective single-center study included patients who underwent levator aponeurosis advancement with or without concomitant skin excision for acquired ptosis. The primary outcome was postoperative margin reflex distance 1 (MRD-1) at 3 months. A linear mixed-effects model was used to evaluate factors associated with postoperative MRD-1, including prostaglandin-related antiglaucoma medication use and previous glaucoma surgery.
RESULTS: Seventy-two eyes from 46 patients were analyzed; 35 received prostaglandin-related antiglaucoma medication, and 37 did not. Mean preoperative MRD-1 was significantly lower in the medication group (0.30 ± 0.82 mm vs 0.85 ± 0.83 mm, P = 0.006). Postoperative MRD-1 at three months did not differ significantly between groups. MRD-1 improvement was greater in the medication-use group (P = 0.024). Prostaglandin-related medication use was not significantly associated with postoperative MRD-1 after adjustment for preoperative MRD-1, age, sex, concomitant skin excision, and previous glaucoma surgery.
CONCLUSION: Eyes administered prostaglandin-related antiglaucoma medication had a lower preoperative MRD-1 than eyes without such medication use. However, postoperative MRD-1 at 3 months was comparable between the groups. Prostaglandin-related medication use was not significantly associated with postoperative MRD-1 after adjustment for previous glaucoma surgery and other covariates.
METHODS: This retrospective single-center study included patients who underwent levator aponeurosis advancement with or without concomitant skin excision for acquired ptosis. The primary outcome was postoperative margin reflex distance 1 (MRD-1) at 3 months. A linear mixed-effects model was used to evaluate factors associated with postoperative MRD-1, including prostaglandin-related antiglaucoma medication use and previous glaucoma surgery.
RESULTS: Seventy-two eyes from 46 patients were analyzed; 35 received prostaglandin-related antiglaucoma medication, and 37 did not. Mean preoperative MRD-1 was significantly lower in the medication group (0.30 ± 0.82 mm vs 0.85 ± 0.83 mm, P = 0.006). Postoperative MRD-1 at three months did not differ significantly between groups. MRD-1 improvement was greater in the medication-use group (P = 0.024). Prostaglandin-related medication use was not significantly associated with postoperative MRD-1 after adjustment for preoperative MRD-1, age, sex, concomitant skin excision, and previous glaucoma surgery.
CONCLUSION: Eyes administered prostaglandin-related antiglaucoma medication had a lower preoperative MRD-1 than eyes without such medication use. However, postoperative MRD-1 at 3 months was comparable between the groups. Prostaglandin-related medication use was not significantly associated with postoperative MRD-1 after adjustment for previous glaucoma surgery and other covariates.