NPJ Parkinson's disease · 2026

Genetic associations between post-traumatic stress disorder and REM-sleep behavior disorder.

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Ghamgosar Shahkhali Morvarid, Liu Lang, Ghamgosar Shahkhali Mohammad H, Yu Eric, Asayesh Farnaz, Ahmad Jamil, Teferra Meron, Arnulf Isabelle, Dodet Pauline, Ju Yo-El, Hu Michele T M, Montplaisir Jacques Y, Gagnon Jean-François, Desautels Alex, Ibrahim Abubaker, Stefani Ambra, Högl Birgit, Aktan-Süzgün Merve, Iranzo Alex, Serradell Mónica, Montini Angelica, Maya Gerard, Gaig Carles, Gigli Gian Luigi, Valente Mariarosaria, Janes Francesco, Bernardini Andrea, Dauvilliers Yves, Sonka Karel, Kemlink David, Dusek Petr, Sommerauer Michael, Tamgüney Gültekin, Figorilli Michela, Puligheddu Monica, Cochen De Cock Valerie, Oertel Wolfgang, Janzen Annette, Antelmi Elena, Mollenhauer Brit, Sixel-Doring Friederike, Terzaghi Michele, Fiamingo Giuseppe, Skorvanek Matej, Kulcsarova Kristina, Abril Beatriz, Ferini-Strambi Luigi, Bušková Jitka, Orso Beatrice, Mattioli Pietro, Arnaldi Dario, Dijkstra Femke, Viaene Mineke, Boeve Bradley F, Ross Owen A, Rouleau Guy A, Neilson Lee E, Elliott Jonathan E, Lim Miranda M, Postuma Ronald B, Gan-Or Ziv

Аннотация

Isolated/idiopathic rapid-eye movement (REM) sleep behavior disorder (iRBD) is, in most cases, an early form of α -synuclein-related neurodegenerative diseases, including Parkinson's disease and dementia with Lewy bodies. Clinical reports suggest that iRBD is more common in individuals with Post-Traumatic Stress Disorder (PTSD) compared to those without PTSD. We conducted polygenic risk score (PRS), genetic correlation, and Mendelian randomization analyses to explore potential genetic and/or causal associations between PTSD and iRBD. Dopamine transporter imaging binding status was also examined in iRBD patients with (N = 6) and without PTSD (N = 32). While not supporting a causal relationship, genetic analyses revealed a significant association between PTSD and iRBD, consistent with the exploratory imaging substudy. These findings suggest that individuals genetically at risk for PTSD may also be at higher risk for iRBD. Further investigation of iRBD in individuals with PTSD may help inform potential neurodegenerative risk.

Genetic associations between post-traumatic stress disorder and REM-sleep behavior disorder.

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Аннотация