International psychogeriatrics · 2026
Comparison of EEG features between patients with and without reduced 123I-MIBG myocardial scintigraphy uptake: A 6-year retrospective study of 230 patients with suspected dementia.
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Omori Hisaki, Hata Masahiro, Shigenobu Kazue, Takahashi Shun, Miyazaki Yuki, Eto Mitsuhiro, Nakagawa Yuta, Hirashima Atsuya, Muto Kanae, Shinosaki Kazuhiro, Ikeda Manabu
Аннотация
OBJECTIVE: Dementia with Lewy bodies (DLB) remains a diagnostic challenge due to its clinical overlap with other dementia-related diseases. Although 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy provides high specificity for DLB and is one of the indicative biomarkers, its application is constrained by substantial cost and limited accessibility. Electroencephalography (EEG), by contrast, is inexpensive and widely available, but currently serves only as a supportive biomarker. The aim of this study is to investigate the association between these biomarkers.
METHODS: This retrospective study included 230 patients who underwent both examinations for DLB evaluation. After removing 66 patients according to the exclusion criteria, the remaining 164 patients were categorized into a reduced uptake group (n = 68) and a non-reduced uptake group (n = 96) based on a heart-to-mediastinum (H/M) ratio. We performed quantitative EEG analysis to calculate the relative power. Group differences in relative power at each electrode were assessed using Welch's t-tests with the Benjamini-Hochberg procedure.
RESULTS: The groups showed no significant differences in age, sex, or cognitive scores. Compared to the non-reduced uptake group, the reduced uptake group exhibited a significant increase (adjusted p < 0.05) in the relative power of delta and theta waves, with the most prominent changes in the posterior regions. Conversely, it showed a widespread and significant decrease (adjusted p < 0.05) in the relative power of beta and gamma waves.
CONCLUSION: This study demonstrated that patients with reduced 123I-MIBG uptake exhibited posterior-dominant slowing and reduced fast-wave activity in EEG, suggesting that EEG may offer additional neurophysiological insights into DLB.
METHODS: This retrospective study included 230 patients who underwent both examinations for DLB evaluation. After removing 66 patients according to the exclusion criteria, the remaining 164 patients were categorized into a reduced uptake group (n = 68) and a non-reduced uptake group (n = 96) based on a heart-to-mediastinum (H/M) ratio. We performed quantitative EEG analysis to calculate the relative power. Group differences in relative power at each electrode were assessed using Welch's t-tests with the Benjamini-Hochberg procedure.
RESULTS: The groups showed no significant differences in age, sex, or cognitive scores. Compared to the non-reduced uptake group, the reduced uptake group exhibited a significant increase (adjusted p < 0.05) in the relative power of delta and theta waves, with the most prominent changes in the posterior regions. Conversely, it showed a widespread and significant decrease (adjusted p < 0.05) in the relative power of beta and gamma waves.
CONCLUSION: This study demonstrated that patients with reduced 123I-MIBG uptake exhibited posterior-dominant slowing and reduced fast-wave activity in EEG, suggesting that EEG may offer additional neurophysiological insights into DLB.