American journal of respiratory and critical care medicine · 2026
Expanded detection of early fibrotic phenotypes using lobar traction bronchiolectasis in lung cancer screening.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Cheng Daryl O, Yamada Daisuke, Azimbagirad Mehran, Bhamani Amyn, Egashira Ryoko, Chapman Robert, McCabe John, Wang Shanshan, Naftel Jennifer, Marguerie Sarah, Wallis Tim, Dunbar Jonathan, Vasudev Pardeep, SUMMIT Consortium, Nair Arjun, Alexander Daniel C, Janes Sam M, Jones Mark G, Selvarajah Brintha, Jacob Joseph
Аннотация
RATIONALE: Lung cancer screening regularly identifies participants with interstitial lung abnormalities (ILA). Existing classification methods may underestimate the prevalence of clinically relevant ILA phenotypes.
OBJECTIVES: Can a classification system for ILAs developed in a lung cancer screening setting identify clinically relevant phenotypes?
METHODS: Classification criteria based on the presence and lobar extent of traction bronchiolectasis (TBe) were developed internally by expert consensus. Categories included: no ILA, non-fibrotic ILA (NF-ILA), fibrotic ILA (F-ILA), and undiagnosed fibrotic ILD (U-ILD). Interobserver agreement was calculated between two readers. Clinical characteristics, respiratory hospitalizations, and survival were compared between participants of different ILA grades.
MEASUREMENTS AND MAIN RESULTS: Eight thousand, one hundred sixty-nine participants were included in the final analysis. TBe showed improved interobserver agreement compared to the American Thoracic Society (ATS) classification, identifying 344 participants (4%) with U-ILD, 86% more than the ATS classification. An additional 405 had F-ILA (5%) and 667 had NF-ILA (8%). Compared to participants without ILA, participants with U-ILD had a higher rate of respiratory hospitalization (IRR = 4.4, 95% CI 2.7-7.5, P < .001) and increased risk of death (aHR = 2.4, 95% CI 1.9-3.0, P < .001). Increasing ILA grade was associated with higher modified Medical Research Council dyspnea scores (OR = 1.1, 95% CI 1.0-1.1, P = .02).
CONCLUSIONS: In a lung cancer screening setting, an ILA scoring system focused on lobar TBe identifies more high-risk participants and demonstrates improved interobserver concordance than the ATS classification. TBe identifies participants with a respiratory phenotype who may warrant further investigation and follow-up.
OBJECTIVES: Can a classification system for ILAs developed in a lung cancer screening setting identify clinically relevant phenotypes?
METHODS: Classification criteria based on the presence and lobar extent of traction bronchiolectasis (TBe) were developed internally by expert consensus. Categories included: no ILA, non-fibrotic ILA (NF-ILA), fibrotic ILA (F-ILA), and undiagnosed fibrotic ILD (U-ILD). Interobserver agreement was calculated between two readers. Clinical characteristics, respiratory hospitalizations, and survival were compared between participants of different ILA grades.
MEASUREMENTS AND MAIN RESULTS: Eight thousand, one hundred sixty-nine participants were included in the final analysis. TBe showed improved interobserver agreement compared to the American Thoracic Society (ATS) classification, identifying 344 participants (4%) with U-ILD, 86% more than the ATS classification. An additional 405 had F-ILA (5%) and 667 had NF-ILA (8%). Compared to participants without ILA, participants with U-ILD had a higher rate of respiratory hospitalization (IRR = 4.4, 95% CI 2.7-7.5, P < .001) and increased risk of death (aHR = 2.4, 95% CI 1.9-3.0, P < .001). Increasing ILA grade was associated with higher modified Medical Research Council dyspnea scores (OR = 1.1, 95% CI 1.0-1.1, P = .02).
CONCLUSIONS: In a lung cancer screening setting, an ILA scoring system focused on lobar TBe identifies more high-risk participants and demonstrates improved interobserver concordance than the ATS classification. TBe identifies participants with a respiratory phenotype who may warrant further investigation and follow-up.