Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego · 2002
[Tissue factor (TF) and inhibitor (TFPI) concentrations in patients with urinary tract tumors and haematological malignancies].
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Radziwon Piotr, Schenk Joachim F, Mazgajska Katarzyna, Boczkowska-Radziwon Barbara, Galar Marzenna, Kłoczko Janusz, Wojtukiewicz Marek Z
Аннотация
The aim of study was to evaluate TF activity and TFPI concentration in patients with haematological malignancies and urinary tract tumors. TFPI concentration and activity and TF concentration were measured in 20 patients suffering from acute myeloblastic leukaemia (AML), 21 patients with chronic myelogenous leukaemia (CML), 17 patients with chronic lymphatic leukaemia (CLL), 16 patients with multiple myeloma (MM) and 65 healthy adults. TFPI and TF concentrations were measured also in patients with renal cell carcinoma (n = 12) and bladder cancer (n = 17) and patients with benign prostatic hyperplasia (BPH) (n = 15). Patients with AML, CML, CLL, and cancer revealed elevated TFPI concentrations. Patients with AML, CML, CLL, MM showed decreased TFPI activity. However TFPI concentration correlated inversely with TFPI activity only in the AML group. No significant changes were observed in TF concentrations in all investigated groups.
Предметные рубрики MeSH
Biomarkers, TumorCarcinoma, Renal CellCase-Control StudiesEnzyme-Linked Immunosorbent AssayFemaleHumansKidney NeoplasmsLeukemiaLeukemia, Lymphocytic, Chronic, B-CellLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia, Myeloid, AcuteLipoproteinsMaleMultiple MyelomaProstatic HyperplasiaThromboplastinUrinary Bladder NeoplasmsUrologic Neoplasms