Medicina clinica · 2026
Predictors of symptomatic atrial fibrillation recurrence and all-cause mortality at 12 months in obese and non-obese patients.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Gupta Shyla, Kalasipudi Rohan, Tharusha Gurusinghe Praveen, Gautam Ayush, Huang Ken, Dababneh Edward, Dhonde Prithviraj, Matta María Gabriela
Аннотация
BACKGROUND AND OBJECTIVE: Obesity is a modifiable risk factor for atrial fibrillation (AF); however, its influence on recurrence and mortality remains controversial. This study aimed to compare clinical characteristics and 12-month outcomes between obese and non-obese patients with AF and to identify predictors of recurrence and mortality.
MATERIALS AND METHODS: A retrospective analysis was conducted on 225 patients hospitalized for AF, classified according to obesity (BMI ≥30kg/m2). The primary outcome was AF-related rehospitalization within 12 months, and the secondary outcome was all-cause mortality. Clinical, biochemical, and sociodemographic data were collected.
RESULTS: Obesity was present in 43% of patients and was associated with younger age, a higher prevalence of sleep apnea, and hypertriglyceridemia. At 12 months, 24.9% of patients were rehospitalized and 14.0% experienced AF recurrence. Obesity (OR 2.84; 95% CI 1.17-6.90; p=0.021) and excessive alcohol consumption (OR 3.49; 95% CI 1.07-11.41; p=0.039) independently predicted AF recurrence. Advanced age, low socioeconomic status, and hypokalaemia were associated with higher mortality, whereas obesity was linked to a lower risk (OR 0.38; 95% CI 0.16-0.95; p=0.038).
CONCLUSIONS: In this cohort, obesity was associated with increased AF recurrence but reduced mortality, supporting the "obesity paradox." Excessive alcohol intake and low socioeconomic status also influenced outcomes, underscoring the need for individualized management strategies.
MATERIALS AND METHODS: A retrospective analysis was conducted on 225 patients hospitalized for AF, classified according to obesity (BMI ≥30kg/m2). The primary outcome was AF-related rehospitalization within 12 months, and the secondary outcome was all-cause mortality. Clinical, biochemical, and sociodemographic data were collected.
RESULTS: Obesity was present in 43% of patients and was associated with younger age, a higher prevalence of sleep apnea, and hypertriglyceridemia. At 12 months, 24.9% of patients were rehospitalized and 14.0% experienced AF recurrence. Obesity (OR 2.84; 95% CI 1.17-6.90; p=0.021) and excessive alcohol consumption (OR 3.49; 95% CI 1.07-11.41; p=0.039) independently predicted AF recurrence. Advanced age, low socioeconomic status, and hypokalaemia were associated with higher mortality, whereas obesity was linked to a lower risk (OR 0.38; 95% CI 0.16-0.95; p=0.038).
CONCLUSIONS: In this cohort, obesity was associated with increased AF recurrence but reduced mortality, supporting the "obesity paradox." Excessive alcohol intake and low socioeconomic status also influenced outcomes, underscoring the need for individualized management strategies.