Onkologie · 2005
Metachronous extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) and peripheral T-cell lymphoma unspecified: histologic, immunophenotypic, and molecular documentation.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Venizelos John, Papadopoulos Nikolaos, Lambropoulou Maria, Nikolaidou Sylvia, Bolioti Sophia, Tamiolakis Demetrio
Аннотация
BACKGROUND: Coexistence of B- and T-cell lymphoid malignancies has been reported sporadically.
CASE REPORT: A 68-year-old woman developed a lymphoid neoplasm in the large intestine and a second lymphoid neoplasm in the esophagus, 24 months after the diagnosis of the first lymphoma. Immunophenotypic analyses were consistent with extranodal marginal zone B-cell mucosa-associated lymphoid tissue type (MALT type) and peripheral T-cell unspecified lymphomas in the large intestine and the esophagus, respectively. The molecular analysis confirmed the B-clonal genotype of the first lymphoma, and disclosed a biclonal genotype of the second one (composite T- and B-cell lymphoma). No evidence of Epstein-Barr virus (EBV) association was shown in either tumor.
CONCLUSION: B- and T-cell neoplasms represent two distinct malignancies rather than progression of the same neoplastic clone.
CASE REPORT: A 68-year-old woman developed a lymphoid neoplasm in the large intestine and a second lymphoid neoplasm in the esophagus, 24 months after the diagnosis of the first lymphoma. Immunophenotypic analyses were consistent with extranodal marginal zone B-cell mucosa-associated lymphoid tissue type (MALT type) and peripheral T-cell unspecified lymphomas in the large intestine and the esophagus, respectively. The molecular analysis confirmed the B-clonal genotype of the first lymphoma, and disclosed a biclonal genotype of the second one (composite T- and B-cell lymphoma). No evidence of Epstein-Barr virus (EBV) association was shown in either tumor.
CONCLUSION: B- and T-cell neoplasms represent two distinct malignancies rather than progression of the same neoplastic clone.
Предметные рубрики MeSH
AgedAntibodies, ViralB-LymphocytesBiomarkers, TumorBiopsyColonic NeoplasmsEpstein-Barr Virus InfectionsEsophageal NeoplasmsEsophagusFemaleGene RearrangementGenes, T-Cell Receptor gammaHerpesvirus 4, HumanHumansImmunoglobulin MImmunophenotypingIntestinal MucosaLymphoma, B-Cell, Marginal ZoneLymphoma, T-Cell, PeripheralMitotic IndexNeoplasm InvasivenessNeoplasms, Second PrimaryPolymerase Chain ReactionT-Lymphocytes