British journal of neurosurgery · 2026
Surgical outcomes of glycerol rhizolysis in trigeminal neuralgia defined by neurovascular compression.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Akkara Yash, Thakrar Param, Akosa Oluchi, Bhat Hamza, Ganguli Ananjan, Das Joe M, Mendoza Nigel
Аннотация
INTRODUCTION: Trigeminal neuralgia (TGN) is often treated with glycerol rhizolysis (GR) when medically refractory, yet the influence of neurovascular compression (NVC) on postoperative outcomes and recurrence remains unclear. We aimed to identify the role of NVC on outcomes following GR.
METHODS: We conducted a retrospective cohort study of adults with medically refractory classical or idiopathic TGN who underwent glycerol rhizolysis between 2014 and 2024. Demographic, clinical, radiological, and surgical variables, including NVC type and severity, were collected. Postoperative pain was assessed using the Barrow Neurological Institute (BNI) scale at discharge and 1 year, with recurrence evaluated across longitudinal follow-up. Multiple linear and Cox proportional hazard regressions identified predictors of postoperative BNI and recurrence, with group comparisons performed using t-tests, ANOVA, and Log-rank tests.
RESULTS: 146 individuals (212 GR procedures) met the inclusion criteria, with a median follow-up of 36 months. At discharge, 81.1% of procedures resulted in favourable pain outcomes (BNI I-III), with 26.4% achieving complete pain relief. At 1 year, 57.5% maintained favourable outcomes, including 19.3% with complete relief. Median time to recurrence was 25.5 months. Postoperative hypoesthesia was more frequent at discharge than at 1 year (11.3% vs. 4.7%, p < 0.05). Increasing age, displaced neurovascular compression, arterial compression, longer symptom duration, and higher preoperative BNI independently predicted worse postoperative BNI scores. Male sex, displaced compression, absence of ipsilateral compression, and higher preoperative BNI were associated with increased risk of recurrence.
CONCLUSION: Neurovascular compression type and severity significantly impact postoperative pain and recurrence after glycerol rhizolysis. Incorporating NVC characteristics into preoperative planning may improve patient selection and treatment outcomes.
METHODS: We conducted a retrospective cohort study of adults with medically refractory classical or idiopathic TGN who underwent glycerol rhizolysis between 2014 and 2024. Demographic, clinical, radiological, and surgical variables, including NVC type and severity, were collected. Postoperative pain was assessed using the Barrow Neurological Institute (BNI) scale at discharge and 1 year, with recurrence evaluated across longitudinal follow-up. Multiple linear and Cox proportional hazard regressions identified predictors of postoperative BNI and recurrence, with group comparisons performed using t-tests, ANOVA, and Log-rank tests.
RESULTS: 146 individuals (212 GR procedures) met the inclusion criteria, with a median follow-up of 36 months. At discharge, 81.1% of procedures resulted in favourable pain outcomes (BNI I-III), with 26.4% achieving complete pain relief. At 1 year, 57.5% maintained favourable outcomes, including 19.3% with complete relief. Median time to recurrence was 25.5 months. Postoperative hypoesthesia was more frequent at discharge than at 1 year (11.3% vs. 4.7%, p < 0.05). Increasing age, displaced neurovascular compression, arterial compression, longer symptom duration, and higher preoperative BNI independently predicted worse postoperative BNI scores. Male sex, displaced compression, absence of ipsilateral compression, and higher preoperative BNI were associated with increased risk of recurrence.
CONCLUSION: Neurovascular compression type and severity significantly impact postoperative pain and recurrence after glycerol rhizolysis. Incorporating NVC characteristics into preoperative planning may improve patient selection and treatment outcomes.