Amelioration of Dominant Dystrophic Epidermolysis Bullosa Ulceration by Combination Gentian Violet and Trichloroacetic Acid Therapy.

INTRODUCTION: Dominant dystrophic epidermolysis bullosa (DDEB) is a hereditary genetic disorder with a mutation of the type VII collagen gene (COL7A1), leading to a destabilized dermal-epidermal junction. Current treatments for DDEB are supportive, and new gene therapies are being developed to target DDEB. However, gene therapy can be expensive.

CASE REPORT: A 59-year-old woman presented with eroded blisters on her right lower extremity. Genetic testing identified a pathogenic COL7A1 mutation, confirming the diagnosis of DDEB. She was treated with 6 weeks of gentian violet and trichloroacetic acid peel, resulting in significant improvement of her lesions.

DISCUSSION: DDEB is characterized by dysregulated inflammation of chronic wounds and aberrant fibroblast activity. Gentian violet and trichloroacetic acid may address inflammation while reducing fibroblast activity and preventing infection. The treatment worked well for the patient, and there was minimal pain with the application of these topical therapies. &nbsp.