Life (Basel, Switzerland) · 2026
Suspected Microplastic-like Particles in Human Gastric Autopsy Samples: An Exploratory Histopathological and Biochemical Study.
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Radu Eugen-Toma, Palade Nastaca Alina, Solomon Crina Cristina, Somcutian Oana Gabriela, Pumnea Manuela Pia, Totan Maria, Mihuț Claudia Maria, Georgescu Cecilia, Atasie Diter, Arseniu Anca Maria, Gligor Felicia Gabriela
Аннотация
BACKGROUND: Human exposure to microplastics (MPs) is an emerging public health concern, yet their presence and pathological significance in gastric tissues remain poorly understood. This study investigated suspected MP-like particles in human gastric autopsy specimens, examining their association with histopathological changes and routine biochemical parameters.
METHODS: A retrospective post-mortem study was conducted on gastric tissue samples from 55 adults who underwent autopsies between 2022 and 2025. Tissue samples were digested using a hydrogen peroxide method, vacuum-filtered, stained with Nile Red, and quantified via ImageJ. Histopathological evaluation using hematoxylin-eosin staining and polarized light microscopy identified tissue-embedded suspected MP-like particles and assessed inflammation, necrosis, and fibrosis. Data were analyzed based on suspected MP-like particle detection status.
RESULTS: Suspected gastric MP-like particles were detected in 15 of 55 cases (27.3%). Most positive cases exhibited a low particle burden (median 1/g). Polarized light microscopy additionally served as a technical assessment tool, revealing birefringent structures measuring 26-84 μm within the gastric mucosa or lumen. All suspected MP-like particle-positive cases showed gastric inflammation compared to 35.0% of suspected MP-like particle-negative cases. Fibrosis and necrosis occurred exclusively in the suspected MP-like particle-positive group but lacked statistical significance. No significant associations were found between suspected MP-like particle detection and demographics, comorbidities, or systemic biochemical markers.
CONCLUSIONS: Suspected gastric MP-like particles were identified in over a quarter of autopsy tissues and were strongly associated with localized gastric inflammation.
METHODS: A retrospective post-mortem study was conducted on gastric tissue samples from 55 adults who underwent autopsies between 2022 and 2025. Tissue samples were digested using a hydrogen peroxide method, vacuum-filtered, stained with Nile Red, and quantified via ImageJ. Histopathological evaluation using hematoxylin-eosin staining and polarized light microscopy identified tissue-embedded suspected MP-like particles and assessed inflammation, necrosis, and fibrosis. Data were analyzed based on suspected MP-like particle detection status.
RESULTS: Suspected gastric MP-like particles were detected in 15 of 55 cases (27.3%). Most positive cases exhibited a low particle burden (median 1/g). Polarized light microscopy additionally served as a technical assessment tool, revealing birefringent structures measuring 26-84 μm within the gastric mucosa or lumen. All suspected MP-like particle-positive cases showed gastric inflammation compared to 35.0% of suspected MP-like particle-negative cases. Fibrosis and necrosis occurred exclusively in the suspected MP-like particle-positive group but lacked statistical significance. No significant associations were found between suspected MP-like particle detection and demographics, comorbidities, or systemic biochemical markers.
CONCLUSIONS: Suspected gastric MP-like particles were identified in over a quarter of autopsy tissues and were strongly associated with localized gastric inflammation.