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Cell · 2026

Multimodal clocks of human aging.

СтатьяНазвание и аннотация: Перевод в очереди
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Li Jiaming, Jiang Beier, Zhang Wei, Hao Junwei, Liu Zhili, Ji Qianzhao, Zheng Yandong, Lu Xiaoyong, Zheng Zikai, Ma Shuai, Fan Yanlin, Gao Dan-Dan, Hou Xiao-Wen, Li Jing, Tang Jiazhen, Jing Yaobin, Geng Lingling, Wu Ruochen, Zhang Baohu, Sun Shuhui, Cai Yusheng, Yan Kaowen, Xiong Muzhao, Dong Chen, Ma Xibo, Xu Gang, Ji Zhejun, Yan Haoteng, Zheng Quan, Huang Honghao, Zhang Li, Li Junming, Jiang Mengmeng, Xu Liu-Jun, Chen Yifan, Qu Geyue, Lei Wan, Wang Hengchao, Ping Jun, Zhou Jia, Yi Ming, Jiang Mingjin, Jing Ying, Ye Wei-Dong, Zhang Xiao, Chu Xi, He Yuting, Zhao Qian, Wu Qi, He Meiling, Ma Lina, Liu Peng, Zhao Liyun, Zhai Qiao-Cheng, Qin Jun, Lu Jie, Yang Xianhe, Zhang Shuo, Xiong Yu, Ren Hua, Yang Wei, Huang Zhanmei, Zhang Jiachen, Zhang Min, Chen Pei, Dong Jian, Zhang Yu, Yan Tingting, Ye Jin-Lin, Huang Ping, Qi Zhigang, Liu Yong, Shuai Jichen, Chen Cheng-Shui, Li Ping, Li Dawei, Xu Xiuhua, Song Xuexian, Li Jingyi, Ping Jiale, Hu Jinghao, Sun Xiaoyan, Ai Jiaqi, Wang Zhengqin, Zhang Yuxin, Yang Peng, Ning Taixin, Yu Yan, He Zan, Zhang Hui, Zhang Tianyang, Yang Yuanhan, Wang Qiaoran, Lin Fangmin, Jin Xiangmei, Chen Xuewei, Ren Jie, Song Moshi, Wang Si, Yang Jiayin, Li Jianming, Song Weihong, He Fuchu, Yang Yun-Gui, Pei Gang, Qu Jing, Zhang Wei, Pu Jun, Zhang Feng, Zhao Guoguang, Zhang Weiqi, Liu Guang-Hui

Аннотация

Human aging is characterized by complex structural and functional decline, but quantifying its heterogeneity and assessing biological age remain challenges. We present the mCAS (multicentric Chinese aging standardized cohort) developed from 2,019 Chinese individuals aged 18-91 years. Integrating high-dimensional clinical, physiological, and molecular-level data, we constructed a three-tiered aging framework: the core capacity clock (CC-clock) to quantify clinical physiological decline, the multimodal clock (MM-clock) with extensive parameter coverage and enhanced predictive precision, and organ-associated aging clocks. Cross-layer analysis demonstrates that plasma protein clocks not only capture chronological age but also serve as efficient proxies for systemic physiological capacity. Leveraging this framework for discovery, we identified the age-dependent accumulation of coagulation factors as a driver of multi-organ senescence and systemic inflammatory activation. This study provides a foundational framework that bridges molecular signatures with functional decline, identifies new biomarkers for aging assessment, and reveals a novel translational driver of aging.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты