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Войти в исследования Clinical oral investigations · 2025
The role of vitamin D deficiency in the development and severity of oral lichen planus: a case-control study.
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Shalaby Rania, Nabil Ghada, Ibrahim Sally, Kotb Ali Aw, Amer Hatem, Afifi Salsabeel
Аннотация
OBJECTIVES: Examine the responsibility of Vitamin D (VD) deficit as a risk element in the development and severity of oral lichen planus (OLP) considering dietary habits, sex, sun exposure, socioeconomic class and psychological factors.
MATERIALS AND METHODS: Blood samples from 35 OLP patients and 35 healthy controls were collected for the analysis of serum VD level (SVDL) by ELISA. Vitamin D deficiency was considered when SVDL was ≤ 20 ng/ml. Additionally, a structured questionnaire was used to analyze other possible confounders.
RESULTS: SVDL were statistically significant greater in the control group than the OLP group (P ≤ 0.001). There was difference between the 3 types of OLP with statistical significance in which the least values for SVDL were in erosive type (P ≤ 0.001). Furthermore, no statistically significant difference was found in SVDL between dysplastic and non-dysplastic lesions. In terms of VD deficiency, a statistically significant distinction was noticed between the two research sets (P ≤ 0.001) and was more pronounced in erosive and atrophic types than reticular types. Depression as well as sun exposure significantly affected number of patients having VD deficiency (P = 0.001, 0.027). Results revealed a statistically significant direct relation between SVDL and the OLP (odds ratio = 1.38; 95%CI = 1.18-1.617).
CONCLUSION: VD deficiency plays a vital role in OLP and the development of more severe forms.
CLINICAL RELEVANCE: It corroborates that VD deficiency is a probable risk factor of OLP and the development of more severe forms considering many confounders.
MATERIALS AND METHODS: Blood samples from 35 OLP patients and 35 healthy controls were collected for the analysis of serum VD level (SVDL) by ELISA. Vitamin D deficiency was considered when SVDL was ≤ 20 ng/ml. Additionally, a structured questionnaire was used to analyze other possible confounders.
RESULTS: SVDL were statistically significant greater in the control group than the OLP group (P ≤ 0.001). There was difference between the 3 types of OLP with statistical significance in which the least values for SVDL were in erosive type (P ≤ 0.001). Furthermore, no statistically significant difference was found in SVDL between dysplastic and non-dysplastic lesions. In terms of VD deficiency, a statistically significant distinction was noticed between the two research sets (P ≤ 0.001) and was more pronounced in erosive and atrophic types than reticular types. Depression as well as sun exposure significantly affected number of patients having VD deficiency (P = 0.001, 0.027). Results revealed a statistically significant direct relation between SVDL and the OLP (odds ratio = 1.38; 95%CI = 1.18-1.617).
CONCLUSION: VD deficiency plays a vital role in OLP and the development of more severe forms.
CLINICAL RELEVANCE: It corroborates that VD deficiency is a probable risk factor of OLP and the development of more severe forms considering many confounders.