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DOI 10.1007/s40123-025-01258-0

Медицинская библиотека · Ophthalmology and therapy · 2025

The Risk of Developing Ocular Involvement Among Behçet's Disease Patients Presenting with Mucocutaneous Involvement at Disease Onset: Data from the International AIDA Network Behçet's Disease Registry.

Vitale Antonio, Caggiano Valeria, Sbalchiero Jessica, Lopalco Giuseppe, Ragab Gaafar, Guerriero Silvana, AlMaglouth Ibrahim, Tufan Abdurrahman, Giacomelli Roberto, Direskeneli Haner, Ruscitti Piero, Hatemi Gülen, Carubbi Francesco, Batu Ezgi Deniz, Ozen Seza, Sota Jurgen, Giardini Henrique Ayres Mayrink, Frassi Micol, Sfikakis Petros P, Gatti Federica, Ammoscato Claudia, Maher Amina, Mahmoud Ayman Abdel-Monem Ahmed, Dammacco Rosanna, Kucuk Hamit, Kardas Riza Can, Cakir Ibrahim Yahya, Öner Fatma Alibaz, Sevik Gizem, Gentile Martina, Karakoc Alican, Alunno Alessia, Emreol Hulya Ercan, Crisafulli Francesca, Laskari Katerina, Ciccia Francesco, Thabet Maissa, Feriel Naceur, Bugatti Serena, Milanesi Alessandra, Chimenti Maria Sole, Monosi Benedetta, Piga Matteo, Floris Alberto, Gavioli Francesco, Chighizola Cecilia Beatrice, Hernández-Rodríguez José, Cattalini Marco, Govoni Marcello, Viapiana Ombretta, Civino Adele, Opris-Belinski Daniela, Gaggiano Carla, Talarico Rosaria, Alemanno Annachiara, Giardina Annarita, Emmi Giacomo, Puttini Piercarlo Sarzi, Maggio Maria Cristina, Parronchi Paola, Portincasa Piero, de-la-Torre Alejandra, Rodríguez-Camelo Laura Daniela, Gentileschi Stefano, Mauro Angela, Sebastiani Gian Domenico, Olivieri Alma Nunzia, Şahin Ali, Rigante Donato, Bilgin Emre, Del Giudice Emanuela, Breda Luciana, De Paulis Amato, Lo Gullo Alberto, Erten Şükran, Tharwat Samar, Fotis Lampros, Maier Armin, Insalaco Antonella, Karamanakos Anastasios, Conforti Alessandro, Gündüz Özgül Soysal, Moshrif Abdelhfeez, Gobbi Francesca Li, Costi Stefania, Bartoloni Elena, Barone Patrizia, Guiducci Serena, Gonzáles-García Andrés, Rodriguez Inés Hernanz, Conti Giovanni, Iagnocco Annamaria, Önen Fatos, Al-Mayouf Sulaiman M, Uçar Didar, Balistreri Alberto, Frediani Bruno, Cantarini Luca, Fabiani Claudia

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Аннотация

INTRODUCTION

Behçet's disease (BD) frequently arises with exclusively mucocutaneous involvement, but some patients will develop major organ involvement, including ocular inflammation. This study aims to assess the patients' demographic and clinical characteristics that may be associated with the development of ocular involvement in patients with BD with exclusively mucocutaneous involvement in the early stages.

METHODS

Patients' data were collected in the International AutoInflammatory Disease Alliance (AIDA) Network registry dedicated to BD.

RESULTS

A total of 328 patients with BD were enrolled, 36 (11%) of whom developed ocular involvement over time. The following variables were significantly associated with the development of ocular inflammation at binary logistic regression: positive family history for BD (OR 4.32, 95% CI 1.16-14.72, p = 0.02), Arab ethnicity (OR 3.6, 95% CI 1.3-9.9, p = 0.01), presence of major oral aphthous ulceration (OR 3.26, 95% CI 1.18-8.99, p = 0.02), pseudofolliculitis plus erythema nodosum (OR 4.58, 95% CI 1.33-15.7, p = 0.016); conversely, white patients/patients of European descent (OR 0.33, 95% CI 0.12-0.91, p = 0.03) and the presence of a low number (one to two) ulcers at genital aphthous flares (OR 0.002, 95% CI ~ 0-0.07, p = 0.0006) were protective against the occurrence of ocular inflammatory manifestations. Genital aphthosis with more than five concurrent ulcers was associated with eye involvement in Arab patients (OR 209.2, 95% CI 5.8-7497, p = 0.003).

CONCLUSIONS

Major oral aphthosis, genital aphthous attacks with more than five concurrent ulcers, erythema nodosum coexisting with pseudofolliculitis, a positive family history of BD, and Arab ethnicity are associated with a higher risk of ocular involvement when BD arises with the sole mucocutaneous involvement.

Для цитирования: Vitale Antonio, Caggiano Valeria, Sbalchiero Jessica, Lopalco Giuseppe, Ragab Gaafar, Guerriero Silvana, AlMaglouth Ibrahim, Tufan Abdurrahman, Giacomelli Roberto, Direskeneli Haner, Ruscitti Piero, Hatemi Gülen, Carubbi Francesco, Batu Ezgi Deniz, Ozen Seza, Sota Jurgen, Giardini Henrique Ayres Mayrink, Frassi Micol, Sfikakis Petros P, Gatti Federica, Ammoscato Claudia, Maher Amina, Mahmoud Ayman Abdel-Monem Ahmed, Dammacco Rosanna, Kucuk Hamit, Kardas Riza Can, Cakir Ibrahim Yahya, Öner Fatma Alibaz, Sevik Gizem, Gentile Martina, Karakoc Alican, Alunno Alessia, Emreol Hulya Ercan, Crisafulli Francesca, Laskari Katerina, Ciccia Francesco, Thabet Maissa, Feriel Naceur, Bugatti Serena, Milanesi Alessandra, Chimenti Maria Sole, Monosi Benedetta, Piga Matteo, Floris Alberto, Gavioli Francesco, Chighizola Cecilia Beatrice, Hernández-Rodríguez José, Cattalini Marco, Govoni Marcello, Viapiana Ombretta, Civino Adele, Opris-Belinski Daniela, Gaggiano Carla, Talarico Rosaria, Alemanno Annachiara, Giardina Annarita, Emmi Giacomo, Puttini Piercarlo Sarzi, Maggio Maria Cristina, Parronchi Paola, Portincasa Piero, de-la-Torre Alejandra, Rodríguez-Camelo Laura Daniela, Gentileschi Stefano, Mauro Angela, Sebastiani Gian Domenico, Olivieri Alma Nunzia, Şahin Ali, Rigante Donato, Bilgin Emre, Del Giudice Emanuela, Breda Luciana, De Paulis Amato, Lo Gullo Alberto, Erten Şükran, Tharwat Samar, Fotis Lampros, Maier Armin, Insalaco Antonella, Karamanakos Anastasios, Conforti Alessandro, Gündüz Özgül Soysal, Moshrif Abdelhfeez, Gobbi Francesca Li, Costi Stefania, Bartoloni Elena, Barone Patrizia, Guiducci Serena, Gonzáles-García Andrés, Rodriguez Inés Hernanz, Conti Giovanni, Iagnocco Annamaria, Önen Fatos, Al-Mayouf Sulaiman M, Uçar Didar, Balistreri Alberto, Frediani Bruno, Cantarini Luca, Fabiani Claudia. The Risk of Developing Ocular Involvement Among Behçet's Disease Patients Presenting with Mucocutaneous Involvement at Disease Onset: Data from the International AIDA Network Behçet's Disease Registry.. Ophthalmology and therapy. 2025. DOI: 10.1007/s40123-025-01258-0.
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