BMC gastroenterology · 2026
Prevalence, anatomic-pathologic findings, and associated factors of nontraumatic ileal perforations among patients with gut perforation: a multicenter cross-sectional study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Waziri Musa Abbas, Vivian Akello, Raymond Atwine, Lauben Amagara Kyomukama, Joel Wandabwa, Edwin Musinguzi, Peter Awio John, Godfroy Nyenke Basara, Sonye Kiyaka, Molle Fabrice, Sikakulya Franck Katembo, Muhumuza Joshua, Kithinji Stephen Mbae, Kagenderezo ByaMungu Pahari, Vahwere Bienfait Mumbere
Аннотация
BACKGROUND: Nontraumatic ileal perforation is a cause of obscure peritonitis characterized by severe toxicity and high mortality. This burden is disproportionately greater in LMICs due to poor hygiene practices, burden of HIV infection, and other comorbidities. This study aimed at determining the prevalence, anatomic-pathologic findings, and factors associated with nontraumatic ileal perforation a multicenter cross‑sectional study at 3 selected hospitals in Uganda.
METHODS: This was a cross-sectional study of 149 consecutive sample participants that used a structured checklist. We conducted logistic regression analyses using SPSS v21.0 (IBM), Variables with p < 0.20 in the bivariate analysis were entered into the multivariable logistic regression model, and p < 0.05 was considered statistically significant.
RESULTS: Nontraumaticileal perforation was more prevalent among males (20.1%; 149) and peasants/farmers (41.6%; 149) of rural residence (22.1%; 149). The majority of the study participants had typhoid perforations (79.1%; 149). Most ileal perforations occurred 20-39 cm from the ileocecal junction (76.4%; 149), a perforation size/diameter of 0.5-1cm was more common (58.1%; 149), and a single isolated perforation was more common (74.4%; 149). However, all perforations mainly occurred at the ante mesenteric border. Being an HIV-positive person was associated with greater odds of developing NTIP than was being a non-HIV-positive person. AOR 8.344, p = 0.015 (p<0.05). Additionally, patients treated with open and closed pit latrines were more likely to develop nontraumatic perforation than were those treated with water flash latrines. AOR 12.971, p = 0.004 (p < 0.05).
CONCLUSION: This study established that nontraumaticileal perforation is more prevalent among male peasants living in rural areas and with typhoid fever and most of ileal perforations were due to typhoid fever.
METHODS: This was a cross-sectional study of 149 consecutive sample participants that used a structured checklist. We conducted logistic regression analyses using SPSS v21.0 (IBM), Variables with p < 0.20 in the bivariate analysis were entered into the multivariable logistic regression model, and p < 0.05 was considered statistically significant.
RESULTS: Nontraumaticileal perforation was more prevalent among males (20.1%; 149) and peasants/farmers (41.6%; 149) of rural residence (22.1%; 149). The majority of the study participants had typhoid perforations (79.1%; 149). Most ileal perforations occurred 20-39 cm from the ileocecal junction (76.4%; 149), a perforation size/diameter of 0.5-1cm was more common (58.1%; 149), and a single isolated perforation was more common (74.4%; 149). However, all perforations mainly occurred at the ante mesenteric border. Being an HIV-positive person was associated with greater odds of developing NTIP than was being a non-HIV-positive person. AOR 8.344, p = 0.015 (p<0.05). Additionally, patients treated with open and closed pit latrines were more likely to develop nontraumatic perforation than were those treated with water flash latrines. AOR 12.971, p = 0.004 (p < 0.05).
CONCLUSION: This study established that nontraumaticileal perforation is more prevalent among male peasants living in rural areas and with typhoid fever and most of ileal perforations were due to typhoid fever.