IJU case reports · 2025
A Case of Interstitial Cystitis With Hunner Lesions Involving Bilateral Ureters.
СтатьяНазвание и аннотация: Перевод в очереди
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Otsuka Satoki, Akiyama Yoshiyuki, Maeda Daichi, Niimi Aya, Hashimoto Kenichi, Kamei Jun, Taguchi Satoru, Yamada Yuta, Sato Yusuke, Yamada Daisuke, Minagawa Tomonori, Ushiku Tetsuo, Homma Yukio, Kume Haruki
Аннотация
INTRODUCTION: Interstitial cystitis with Hunner lesion (IC/HL) is an enigmatic, chronic inflammatory disease of the urinary bladder. Few documented cases have reported the IC/HL involving the upper urinary tract.
CASE PRESENTATION: A 51-year-old Japanese woman with IC/HL developed bilateral ureteral stenosis and associated hydronephrosis, resulting in increased serum creatinine concentrations. Cystography showed no evidence of bilateral vesicoureteral reflux or bladder deformity. Ureteroscopy showed severe ureteral stenosis due to mucosal hyperplasia at the mid/upper levels of both ureters, leading to the insertion of bilateral ureteral stents. Histological examination of the ureteral lesions showed similar chronic inflammatory changes to the bladder lesions, which were compatible with IC/HL. Bilateral ureteral stenosis persisted after a two-year corticosteroid treatment (prednisolone, 7.5 mg/day), while IC/HL symptoms have disappeared.
CONCLUSION: IC/HL could involve the upper ureters, and thus regular follow-up imaging of upper urinary tracts in patients with IC/HL is warranted.
CASE PRESENTATION: A 51-year-old Japanese woman with IC/HL developed bilateral ureteral stenosis and associated hydronephrosis, resulting in increased serum creatinine concentrations. Cystography showed no evidence of bilateral vesicoureteral reflux or bladder deformity. Ureteroscopy showed severe ureteral stenosis due to mucosal hyperplasia at the mid/upper levels of both ureters, leading to the insertion of bilateral ureteral stents. Histological examination of the ureteral lesions showed similar chronic inflammatory changes to the bladder lesions, which were compatible with IC/HL. Bilateral ureteral stenosis persisted after a two-year corticosteroid treatment (prednisolone, 7.5 mg/day), while IC/HL symptoms have disappeared.
CONCLUSION: IC/HL could involve the upper ureters, and thus regular follow-up imaging of upper urinary tracts in patients with IC/HL is warranted.