The relationship between cardiometabolic index and hyperuricemia and gout in Korean adults: the 8th Korean National Health and Nutrition Examination Survey (2019-2021).

OBJECTIVES

The cardiometabolic index (CMI) is a promising indicator for predicting cardiovascular diseases, but its relationship with hyperuricemia and gout is unclear. The present study was conducted to assess the association between CMI and uric acid (UA) and gout in Korean adults.

MATERIALS AND

METHODS

This study used data from 16,234 adults aged 20 or older from the 8th Korean National Health and Nutrition Examination Survey (2019 - 2021).

RESULTS

There were several key findings in the present study. First, after adjustment for related variables and with quartile 1 of CMI as a reference, the odds ratios (ORs) of hyperuricemia (UA ≥ 8.0 mg/dL in men or ≥ 7.0 mg/dL in women) were significantly higher in quartile 2 [2.164 (95% confidence interval [CI], 1.810-2.588)], quartile 3 of CMI [3.105 (95% CI, 2.604-3.704)], and quartile 4 of CMI [4.938 (95% CI, 4.142-5.886)]. Second, after adjustment for related variables and with quartile 1 of CMI as a reference, the ORs of gout were significantly higher in quartile 4 of CMI [1.850 (95% CI, 1.158-2.956)]. Third, CMI was significant for predicting hyperuricemia (area under the ROC curve [AUC], 0.687; 95% CI, 0.676-0.699; p < 0.001) and gout (AUC, 0.680; 95% CI, 0.651-0.710; p < 0.001).

CONCLUSIONS

CMI was positively associated with hyperuricemia in Korean adults. In addition, an increased CMI is a significant indicator for predicting gout. Key Points • CMI was positively associated with uric acid level. • CMI was positively associated with hyperuricemia. • An increased CMI was associated with an increased prevalence of gout. • An increased CMI can be a useful indicator for predicting hyperuricemia and gout.