Capsule endoscopy in young patients with iron deficiency anaemia and negative bidirectional gastrointestinal endoscopy.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Yung Diana E, Rondonotti Emanuele, Giannakou Andry, Avni Tomer, Rosa Bruno, Toth Ervin, Lucendo Alfredo J, Sidhu Reena, Beaumont Hanneke, Ellul Pierre, Negreanu Lucian, Jiménez-Garcia Victoria Alejandra, McNamara Deidre, Kopylov Uri, Elli Luca, Triantafyllou Konstantinos, Shibli Fahmi, Riccioni Maria Elena, Bruno Mauro, Dray Xavier, Plevris John N, Koulaouzidis A, And the Capsule Endoscopy in Young Patients with IDA research group, Argüelles-Arias Federico, Becq Aymeric, Branchi Federica, Tejero-Bustos María Ángeles, Cotter Jose, Eliakim Rami, Ferretti Francesca, Gralnek Ian M, Herrerias-Gutierrez Juan Manuel, Hussey Mary, Jacobs Maarten, Johansson Gabriele Wurm, McAlindon Mark, Montiero Sara, Nemeth Artur, Pennazio Marco, Rattehalli Deepa, Stemate Ana, Tortora Annalisa, Tziatzios Georgios
Аннотация
MATERIALS AND METHODS: This was a retrospective, multicentre study (2010-2015) in consecutive, young patients (≤50 years) from 18 centres/12 countries, with negative bidirectional gastrointestinal (GI) endoscopy undergoing SBCE for IDA. Exclusion criteria: previous/ongoing obscure-overt GI bleeding; age <19 or >50 years; comorbidities associated with IDA. Data retrieved: SBCE indications; prior investigations; medications; SBCE findings; final diagnosis. Clinical and laboratory data were analysed by multivariate logistic regression.
RESULTS: Data on 389 young IDA patients were retrieved. In total, 169 (43.4%) were excluded due to incomplete clinical data; data from 220 (122F/98M; mean age 40.5 ± 8.6 years) patients were analysed. Some 71 patients had at least one clinically significant SBCE finding (DY: 32.3%). They were divided into two groups: neoplastic pathology (10/220; 4.5%), and non-neoplastic but clinically significant pathology (61/220; 27.7%). The most common significant but non-neoplastic pathologies were angioectasias (22/61) and Crohn's disease (15/61). On multivariate analysis, weight loss and lower mean corpuscular volume(MCV) were associated with significant SB pathology (OR: 3.87; 95%CI: 1.3-11.3; p = 0.01; and OR: 0.96; 95%CI: 0.92-0.99; p = 0.03; respectively). Our model also demonstrates association between use of antiplatelets and significant SB pathology, although due to the small number of patients, definitive conclusions cannot be drawn.
CONCLUSION: In IDA patients ≤50 years with negative bidirectional GI endoscopy, overall DY of SBCE for clinically significant findings was 32.3%. Some 5% of our cohort was diagnosed with SB neoplasia; lower MCV or weight loss were associated with higher DY for SB pathology.