[Alterations in the clinical course of hypertensive disease during the last 25 years].

We undertook analysis of 234 case histories of the patients with HD dated 1985-1987 (group 1) and 2010-2012 (group 2). It showed differences in clinical manifestations of HD between the two periods. First, "cerebral" complaints were less frequent in group 2 while functional state of the cardiovascular system (tolerance of physical load) and efficacy of hypotensive therapy improved. Second, decreased AP did not exclude progression of atherosclerosis and its complications in the presence of other risk factors. MS components (increased body mass, dyslipidemia, hyperglycemia) were more common in group 2 which suggests the necessity of combined prophylaxis of cardiovascular catastrophes. Third, changes in daily AP profile in group 2 require more extensive use of 24 hr AP monitoring for the choice of hypotensive therapy and estimation of its efficacy at specified time. Fourth, modern methods for the treatment of AH slow down the development of renal symptoms of AH.